ethyl N-(4-propoxyphenylmethyl)piperidin-4-yl carboxylate | 169610-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: ethyl N-(4-propoxyphenylmethyl)piperidin-4-yl carboxylate
• 英文别名: ethyl N-(4-propoxyphenylmethyl)piperidin-4-ylcarboxylate；ethyl 1-[(4-propoxyphenyl)methyl]piperidine-4-carboxylate
• CAS: 169610-45-1
• 化学式: C₁₈H₂₇NO₃
• 分子量: 305.417
• InChiKey: SZSZBPAIDJGTBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl N-(4-propoxyphenylmethyl)piperidin-4-yl carboxylate 、 对溴三氟甲氧基苯 在 碘 作用下， 以 四氢呋喃 为溶剂， 生成 N-(4-propoxyphenylmethyl)-4-[bis(4-trifluoromethoxyphenyl)hydroxymethyl]piperidine
  参考文献：
  名称：

  Insecticidal N-(substituted arylmethyl)-4-[bis(substituted

  摘要：

  公开了具有以下结构的化合物，相应的N-氧化物和农业可接受的盐作为有效的杀虫剂：##STR1## 其中U从--(CH.sub.2).sub.n--和乙烯基中选择；Q从氢、羟基、硫醇和氟中选择；R从##STR2## 中选择，其中V从氢、卤素、烷基、卤代烷基、烷氧基、烷基硫基、烷基亚砜基、烷基硅氧基、二烷基氨基、氰基、硝基、羟基和苯基中选择；Y和Z独立地从氢和烷氧基中选择；W和X结合在一起是--OCH.sub.2 CH.sub.2 O--，--CH.sub.2 C(CH.sub.3).sub.2 O--，--OC(CH.sub.3).sub.2 O--或--N.dbd.C(C.sub.2 H.sub.5)O--；R.sup.1和R.sup.2独立地从用卤素、烷基、卤代烷基、卤代烷氧基、烷氧基烷基、羟基、芳基硫基、烷氧基、二烷基氨基、二烷基氨基磺酰基、羟基烷基氨基羰基、烷基砜氧基和卤代烷基砜氧基取代的苯基中选择；n为1、2或3。

  公开号：

  US05639763A1
• 作为产物：
  描述：

  哌啶-4-甲酸乙酯 、 4-丙氧基苯甲醛 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 生成 ethyl N-(4-propoxyphenylmethyl)piperidin-4-yl carboxylate
  参考文献：
  名称：

  Insecticidal N-(substituted arylmethyl)-4-[bis(substituted

  摘要：

  公开了具有以下结构的化合物，相应的N-氧化物和农业可接受的盐作为有效的杀虫剂：##STR1## 其中U从--(CH.sub.2).sub.n--和乙烯基中选择；Q从氢、羟基、硫醇和氟中选择；R从##STR2## 中选择，其中V从氢、卤素、烷基、卤代烷基、烷氧基、烷基硫基、烷基亚砜基、烷基硅氧基、二烷基氨基、氰基、硝基、羟基和苯基中选择；Y和Z独立地从氢和烷氧基中选择；W和X结合在一起是--OCH.sub.2 CH.sub.2 O--，--CH.sub.2 C(CH.sub.3).sub.2 O--，--OC(CH.sub.3).sub.2 O--或--N.dbd.C(C.sub.2 H.sub.5)O--；R.sup.1和R.sup.2独立地从用卤素、烷基、卤代烷基、卤代烷氧基、烷氧基烷基、羟基、芳基硫基、烷氧基、二烷基氨基、二烷基氨基磺酰基、羟基烷基氨基羰基、烷基砜氧基和卤代烷基砜氧基取代的苯基中选择；n为1、2或3。

  公开号：

  US05639763A1

文献信息

• Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]p
  申请人：FMC Corporation

  公开号：US05569664A1

  公开（公告）日：1996-10-29

  Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is selected from ##STR2## Q is selected from hydrogen, hydroxy, sulfhydryl, and fluorine; R is selected from a heterocycle having 5 or 6 ring atoms, optionally fused to a benzene ring, and ##STR3## wherein V, W, X, Y, Z are as defined in the specification.

  以下结构化合物，对应的N-氧化物和农业可接受的盐，被披露为有效的杀虫剂：##STR1## 其中U从##STR2## 中选择，Q从氢、羟基、硫醇和氟中选择；R从具有5个或6个环原子的杂环中选择，可选地融合到苯环和##STR3## 中选择，其中V、W、X、Y、Z如规范中定义。
• Insecticidal compositions containing n-(substituted
  申请人：FMC Corporation

  公开号：US06017931A1

  公开（公告）日：2000-01-25

  Compositions containing compounds of the following structure, some of which are novel, and the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is --(CH.sub.2).sub.n --; Q is hydroxy; R is ##STR2## in which V, W, and Z are each hydrogen; X is selected from alkoxy, haloalkoxy, alkoxyalkyl, cycloalkylalkoxy, halocycloalkylalkoxy, alkoxycarbonyl, haloalkoxycarbonyl, cycloalkylalkoxycarbonyl, halocycloalkylalkoxycarbonyl, alkoxyalkoxycarbonyl, alkoxycarbonylamino, haloalkoxycarbonylamino, cycloalkylalkoxycarbonylamino, halocycloalkylalkoxycarbonylamino, alkylaminocarbonyl, haloalkylaminocarbonyl, cyanoalkoxycarbonylamino, phenylcarbonylamino, and phenoxycarbonyl, each cycloalkyl moiety or phenyl ring optionally substituted with halogen; Y is selected from hydrogen and halogen; n is 1, 2, or 3; R.sup.1 and R.sup.2 are independently selected from phenyl or pyridyl, each substituted with haloalkyl, haloalkoxy, or alkylthio; with the proviso that each aliphatic moiety contains not more than 6 carbon atoms, and halogen means bromine, chlorine or fluorine.

  本发明涉及含有以下结构的化合物，其中一些是新颖的，以及对应的N-氧化物和农业可接受的盐，作为有效的杀虫剂：##STR1## 其中U为--(CH.sub.2).sub.n --; Q为羟基; R为##STR2## 其中V、W和Z均为氢; X选自烷氧基、卤代烷氧基、烷氧基烷基、环烷基烷氧基、卤代环烷基烷氧基、烷氧羰基、卤代烷氧羰基、环烷基烷氧羰基、卤代环烷基烷氧羰基、烷氧基烷氧羰基、烷氧羰基氨基、卤代烷氧羰基氨基、环烷基烷氧羰基氨基、卤代环烷基烷氧羰基氨基、烷基氨基羰基、卤代烷基氨基羰基、氰基烷氧羰基氨基、苯基羰基氨基和苯氧羰基，每个环烷基或苯环可选择地取代卤素; Y选自氢和卤素; n为1、2或3; R.sup.1和R.sup.2独立地选自取代有卤代烷基、卤代烷氧基或烷基硫的苯基或吡啶基，其中每个脂肪族基含有不超过6个碳原子，卤素表示溴、氯或氟。
• Insecticidal N-(substituted arylmethyl)-4-\x9bbis(substituted
  申请人：FMC Corporation

  公开号：US05795901A1

  公开（公告）日：1998-08-18

  Compounds of the following structure are disclosed as effective insecticides: ##STR1## in which Q is hydroxy; U is --(CH.sub.2).sub.n --, where n is 1; R is ##STR2## in which V, W, Y, and Z are each hydrogen; X is alkoxy, cycloalkylalkoxy, alkoxycarbonyl, alkoxycarbonylamino, or a five- or six-membered heteroaryl or heteroaryloxy, each heteroaryl optionally substituted with halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl, or haloalkoxyalkyl; R.sup.1 and R.sup.2 are independently selected from haloalkyl; phenyl substituted with halogen, halothio, haloalkyl, or haloalkoxy; or a five- or six-membered heteroaryl substituted with halogen or haloalkyl; R.sup.3 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, dialkylaminoalkyl, alkylaminocarbonyloxyalkyl, alkylthioalkyl, alkylsulfonylalkyl, alkylcarbonyloxyalkyl, alkoxycarbonylalkyl, carboxyalkyl, carboxyarylalkyl, arylcarbonyl, sulfonato, or sulfonatoalkyl, and may bear a negative charge resulting in an inner salt; and a separate anion is chloride, bromide, iodide, or an phenyl or alkyl sulfate or sulfonate; with the proviso that at least one of R.sup.1 and R.sup.2 is phenyl substituted in the para position or pyrid-2-yl or pyrimidin-2-yl, each substituted in the the 5-position; each aliphatic moiety contains not more than 4 carbon atoms, except that R.sup.3 may contain up to eighteen carbon atoms; halogen means bromine, chlorine, or fluorine; each heteroaryl contains from 1 to 4 nitrogen atoms, or 1 or 2 oxygen or sulfur atoms, or 1 or 2 nitrogen atoms and an oxygen or sulfur atom.

  以下结构的化合物被披露为有效的杀虫剂：## STR1 ## 其中Q为羟基；U为-(CH2)n-，其中n为1；R为## STR2 ## 其中V、W、Y和Z均为氢；X为烷氧基、环烷基烷氧基、烷氧羰基、烷氧羰基氨基或含五元或六元杂环的杂环氧基，每个杂环可选地用卤素、氰基、烷基、卤代烷基、烷氧基、卤代烷氧基、烷氧基烷基或卤代烷氧基烷基取代；R1和R2分别选自卤代烷基；用卤素、卤硫、卤代烷基或卤代烷氧基取代的苯基；或用卤代烷基取代的含五元或六元杂环；R3为烷基、卤代烷基、羟基烷基、烷氧基烷基、二烷基氨基烷基、烷基氨基羰酰氧烷基、烷基硫基烷基、烷基磺酰基烷基、烷基羰酰氧烷基、烷氧羰基烷基、羧基烷基、芳基羧基、磺酸盐或磺酸盐烷基，并且可能带有负电荷形成内盐；另外还有一个阴离子，可以是氯离子、溴离子、碘离子或苯基或烷基硫酸盐或磺酸盐；但至少有一个R1和R2是用卤代苯基在对位或用吡啶-2-基或嘧啶-2-基在5位取代的；每个脂肪族基团含不超过4个碳原子，除了R3可以含有多达18个碳原子；卤素表示溴、氯或氟；每个杂环含有1至4个氮原子，或1或2个氧或硫原子，或1或2个氮原子和1个氧或硫原子。
• Insecticidal N-(substituted arylmethyl)-4[bis(substituted phenyl or pyridyl)methyl] piperidines
  申请人：FMC Corporation

  公开号：US06214845B1

  公开（公告）日：2001-04-10

  Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: in which U is —(CH2)n—; Q is hydroxy; R is in which V, W, Y, and Z are each hydrogen; X is a five- or six-membered heterocycle; optionally substituted with halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl, haloalkoxyalkyl, or aminocarbonyl; and the heterocycle is optionally connected to the phenyl ring through a —O—, —S—, —(CH2)p, —C(O)—, or —O—(CR3R4)q linkage; R1 and R2 are independently selected from phenyl or pyridyl substituted with haloalkyl or haloalkoxy; R3 and R4 are independently selected from hydrogen and methyl; n and p are independently 1, 2, or 3; and q is 1 or 2; with the proviso that at least one of R1 and R2 is substituted in the para position; no more than two of R3 and R4 are methyl; each aliphatic moiety contains not more than 4 carbon atoms; halogen means bromine, chlorine, or fluorine; each heterocycle contains from 1 to 4 nitrogen atoms, or 1 or 2 oxygen or sulfur atoms, or 1 or 2 nitrogen atoms and an oxygen or sulfur atom; and the corresponding N-oxides and agriculturally acceptable salts.

  以下结构的化合物，相应的N-氧化物和农业可接受的盐被披露为有效的杀虫剂：其中U为-(CH2)n-; Q为羟基; R为其中V、W、Y和Z均为氢; X为五元或六元杂环; 可选地用卤素、氰基、烷基、卤代烷基、烷氧基、卤代烷氧基、烷氧基烷基、卤代烷氧基烷基或氨基羰基取代; 且杂环可通过-O-、-S-、-( )p、-C(O)-或-O-(CR3R4)q连接到苯环上; R1和R2独立地选自取代有卤代烷基或卤代烷氧基的苯基或吡啶基; R3和R4独立地选自氢和甲基; n和p独立地为1、2或3; q为1或2; 前提是R1和R2中至少有一个在对位上被取代; R3和R4中不超过两个是甲基; 每个脂肪族基团含有不超过4个碳原子; 卤素表示溴、氯或氟; 每个杂环含有1至4个氮原子，或1或2个氧或硫原子，或1或2个氮原子和一个氧或硫原子; 以及相应的N-氧化物和农业可接受的盐。
• Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl or
  申请人：FMC Corporation

  公开号：US06030987A1

  公开（公告）日：2000-02-29

  Compounds of structure (I) ##STR1## the corresponding N-oxides and agriculturally acceptable salts are disclosed as effective insecticides. In said formula, U is --(CH.sub.2)n--; Q is hydroxy, R is formula (II) ##STR2## in which V, W, Y and Z are hydrogen; X is a five- or six-membered heterocycle optionally substituted; and the heterocycle is optionally connected to the phenyl ring through a --O--, --S-- --CH.sub.2)p--, or --O(CR.sup.3 R.sup.4)q linkage; R.sup.1 and R.sup.2 are independently selected from phenyl or pyridyl substituted with haloalkyl or haloalkoxy; R.sup.3, R.sup.4, n, p, and 1 are as defined in the specification.

  结构式（I）的化合物##STR1##及其相应的N-氧化物和农业上可接受的盐被披露为有效的杀虫剂。在该式中，U为--(CH.sub.2)n--；Q为羟基；R为式（II）##STR2##其中V、W、Y和Z为氢；X为一个五元或六元杂环，可选地被取代；并且该杂环可通过--O--、--S--、--CH.sub.2)p--或--O(CR.sup.3R.sup.4)q连接到苯环上；R.sup.1和R.sup.2分别选择取代有卤代烷基或卤代氧基的苯基或吡啶基；R.sup.3、R.sup.4、n、p和1如规范中所定义。