N,N-diphenyl-2-[4-(phenyl-pyridin-2-yl-methyl)-piperazin-1-yl]-acetamide | 866562-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N,N-diphenyl-2-[4-(phenyl-pyridin-2-yl-methyl)-piperazin-1-yl]-acetamide
• 英文别名: N,N-diphenyl-2-[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]acetamide
• CAS: 866562-80-3
• 化学式: C₃₀H₃₀N₄O
• 分子量: 462.594
• InChiKey: WXXLGOMQNIVFQX-UHFFFAOYSA-N

物化性质

• 沸点：
  651.3±55.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  39.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Diarylamine derivatives as calcium channel blockers
  申请人：Pajouhesh Hassan

  公开号：US20050227999A1

  公开（公告）日：2005-10-13

  Compounds which are derivatives of diarylamine substituted piperazine and amino-piperidine are useful in treating conditions mediated by calcium ion channel activity.

  衍生自二芳基胺基哌嗪和氨基哌啶的化合物在治疗受钙离子通道活性介导的疾病方面具有用处。
• Substituted isoquinolinones
  申请人：Scarborough M. Robert

  公开号：US20050113399A1

  公开（公告）日：2005-05-26

  Isoquinolinone compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.

  提供了一些异喹啉酮化合物，这些化合物对于抑制ADP-血小板聚集非常有用，特别是在治疗血栓形成和与血栓形成相关的疾病或疾病方面。
• DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
  申请人：Neuromed Pharmaceuticals, Ltd.

  公开号：EP1745042A1

  公开（公告）日：2007-01-24
• [EN] DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS<br/>[FR] DERIVES DE DIARYLAMINE UTILISES COMME BLOQUANTS DES CANAUX CALCIQUES
  申请人：NEUROMED TECH INC

  公开号：WO2005097779A1

  公开（公告）日：2005-10-20

  N-diarylaminoalkyl-substituted piperazine/4-aminopiperidine compounds of formula (1) are disclosed, wherein each of A and B is independently a 6-membered aromatic or nonaromatic, carbocyclic or heterocyclic moiety or is an aminoalkyl and wherein one and only one of A and B may be H or alkyl (1-8C) or wherein A and B together form an optionally substituted 6-membered aromatic of nonaromatic, carbocyclic or heterocyclic moiety; R1 is H or alkyl (1-8C), Z is N or CHNR2 wherein R2 is H or alkyl (1-8C), X is straight chain alkylene (1-4C) wherein optionally at least one carbon adjacent to a nitrogen is in the form of C=0; each R3 is an independent substituent; n=0-2; Ar is a six-membered aromatic or heteroaromatic ring; wherein each cyclic moiety included in A or B each Ar moiety in formula (1) may be substituted by one or more substituents. These compounds and salts or conjugated thereof are able to block N-type and T-type calcium channels and are useful for treating conditions mediated by calcium ion channel activity such as chronic pain.