(Z)-1-methyl-5-((2-(4-phenylpiperazin-1-yl)pyrimidin-4-yl)methylene)imidazolidine-2,4-dione | 1332366-66-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (Z)-1-methyl-5-((2-(4-phenylpiperazin-1-yl)pyrimidin-4-yl)methylene)imidazolidine-2,4-dione
• 英文别名: (5Z)-1-methyl-5-[[2-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]methylidene]imidazolidine-2,4-dione
• CAS: 1332366-66-1
• 化学式: C₁₉H₂₀N₆O₂
• 分子量: 364.407
• InChiKey: BMHOIMSADPQREP-SSZFMOIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Imidazole-2,4-Dione Inhibitors of Casein Kinase 1
  申请人：Baldino Carmen M.

  公开号：US20120316155A1

  公开（公告）日：2012-12-13

  Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), the TGFβ pathway and/or the Wnt pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), the TGFβ pathway and/or the Wnt pathway.

  本发明涉及一些化合物，其中包括这些化合物的药物组合物，以及这些化合物和组合物作为酪氨酸激酶1（例如CK1γ）、TGFβ途径和/或Wnt途径的调节剂的用途。本发明还涉及用于治疗或预防一系列治疗适应症的用途，这些治疗适应症至少部分归因于酪氨酸激酶1（例如CK1γ）、TGFβ途径和/或Wnt途径的异常生理活动。
• US9073903B2
  申请人：——

  公开号：US9073903B2

  公开（公告）日：2015-07-07
• [EN] IMIDAZOLE-2, 4-DIONE INHIBITORS OF CASEIN KINASE 1<br/>[FR] INHIBITEURS IMIDAZOLE-2, 4-DIONE DE LA CASÉINE KINASE 1
  申请人：JASCO PHARMACEUTICALS LLC

  公开号：WO2011103289A2

  公开（公告）日：2011-08-25

  Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), the TGFβ pathway and/or the Wnt pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), the TGFβ pathway and/or the Wnt pathway.