2-diethylamino-6-nitrooxazolo<4,5-b>pyridine | 150832-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶唑并吡啶类
• 英文名称: 2-diethylamino-6-nitrooxazolo<4,5-b>pyridine
• 英文别名: N,N-diethyl-6-nitro-[1,3]oxazolo[4,5-b]pyridin-2-amine
• CAS: 150832-68-1
• 化学式: C₁₀H₁₂N₄O₃
• 分子量: 236.23
• InChiKey: QWCYGQHHASJVEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  88
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-diethylamino-6-nitrooxazolo<4,5-b>pyridine 在 palladium on activated charcoal 环己烯 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以87%的产率得到6-amino-2-diethylaminooxazolo<4,5-b>pyridine
  参考文献：
  名称：

  Oxazolo[4,5-b]pyridines. Regiochemistry of Electrophilic Substitution in the 2-Diethylaminooxazolo[4,5-b]pyridine System: Synthesis of 6-Substituted Derivatives

  摘要：

  Electrophilic substitution occurs regiospecifically at C-6 in the 2-diethylaminooxazolo-[4,5-b]pyridine system to provide 6-nitro and 6-halo derivatives. The 6-nitro compound is readily convened to the 6-amino derivative which may be further elaborated by standard methods to provide more complex derivatives.

  DOI：

  10.1080/00397919308011218
• 作为产物：
  描述：

  2-diethylaminooxazolo<4,5-b>pyridine 在 硫酸 、 硝酸 作用下， 反应 16.0h， 以70%的产率得到2-diethylamino-6-nitrooxazolo<4,5-b>pyridine
  参考文献：
  名称：

  Oxazolo[4,5-b]pyridines. Regiochemistry of Electrophilic Substitution in the 2-Diethylaminooxazolo[4,5-b]pyridine System: Synthesis of 6-Substituted Derivatives

  摘要：

  Electrophilic substitution occurs regiospecifically at C-6 in the 2-diethylaminooxazolo-[4,5-b]pyridine system to provide 6-nitro and 6-halo derivatives. The 6-nitro compound is readily convened to the 6-amino derivative which may be further elaborated by standard methods to provide more complex derivatives.

  DOI：

  10.1080/00397919308011218

文献信息

• Oxazolo[4,5-<i>b</i>]pyridines. Regiochemistry of Electrophilic Substitution in the 2-Diethylaminooxazolo[4,5-<i>b</i>]pyridine System: Synthesis of 6-Substituted Derivatives
  作者：O. William Lever、Harvey M. Werblood、Ronald K. Russell

  DOI：10.1080/00397919308011218

  日期：1993.5

  Electrophilic substitution occurs regiospecifically at C-6 in the 2-diethylaminooxazolo-[4,5-b]pyridine system to provide 6-nitro and 6-halo derivatives. The 6-nitro compound is readily convened to the 6-amino derivative which may be further elaborated by standard methods to provide more complex derivatives.