4'-cyano-6-methylbiphenyl-3-carboxylic acid [6-(4-isoquinolin-5-ylmethylpiperazin-1-yl)pyridin-3-yl]amide | 956698-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4'-cyano-6-methylbiphenyl-3-carboxylic acid [6-(4-isoquinolin-5-ylmethylpiperazin-1-yl)pyridin-3-yl]amide
• 英文别名: 3-(4-cyanophenyl)-N-[6-[4-(isoquinolin-5-ylmethyl)piperazin-1-yl]pyridin-3-yl]-4-methylbenzamide
• CAS: 956698-83-2
• 化学式: C₃₄H₃₀N₆O
• 分子量: 538.652
• InChiKey: FLSMAWGIRNOOFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• BIPHENYLCARBOXAMIDE DERIVATIVES AS HEDGEHOD PATHWAY MODULATORS
  申请人：Dierks Christine

  公开号：US20100197659A1

  公开（公告）日：2010-08-05

  The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

  该发明提供了一种调节刺猬信号通路活性的方法。具体来说，该发明提供了一种抑制由于Ptc功能丧失、刺猬功能增强、smoothened功能增强或Gli功能增强等表型引起的异常生长状态的方法，包括将细胞与化合物I式的足够量接触。
• COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
  申请人：Gao Wenqi

  公开号：US20090203666A1

  公开（公告）日：2009-08-13

  The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

  本发明提供了一种调节刺猬信号通路活性的方法。具体而言，本发明提供了一种通过接触细胞与化合物I的足够量来抑制由于Ptc功能缺失、刺猬功能增强、平滑蛋白功能增强或Gli功能增强等表型引起的异常生长状态的方法。
• Compounds and compositions as hedgehog pathway modulators
  申请人：IRM LLC

  公开号：EP2363393A1

  公开（公告）日：2011-09-07

  The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

  本发明提供了一种调节刺猬信号通路活性的方法。特别是，本发明提供了一种抑制由 Ptc 功能缺失、hedgehog 功能增益、smoothened 功能增益或 Gli 功能增益等表型导致的异常生长状态的方法，该方法包括使细胞与足量的式 I 化合物接触。
• SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS
  申请人：Novartis AG

  公开号：EP2346499A1

  公开（公告）日：2011-07-27
• Leukemia Treatment
  申请人：Copland Mhairi

  公开号：US20110039850A1

  公开（公告）日：2011-02-17

  A combination of a BCR-ABL inhibitor and a hedgehog pathway inhibitor for the treatment of leukemia.