4-氨基哌啶-1-羧酸乙酯单盐酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-氨基哌啶-1-羧酸乙酯单盐酸盐
• 英文名称: 4-Amino-piperidine-1-carboxylic acid ethyl ester; hydrochloride
• 英文别名: ethyl 4-aminopiperidine-1-carboxylate;hydron;chloride
• 化学式: C₈H₁₆N₂O₂*ClH
• 分子量: 208.688
• InChiKey: SVFZMEVHUVJQMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.99
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4’-(三氟甲基)联苯-4-甲醛 、 4-氨基哌啶-1-羧酸乙酯单盐酸盐 以 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  AZOLE HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE

  摘要：

  本发明涉及制药化学领域，特别是一种由通式（I）、（II）或（III）表示的新型类唑化合物，以及其制备方法，以这些化合物为活性成分的药物组合物，以及在制备用于治疗与Lp-PLA2酶活性相关疾病的药物中使用这些唑化合物和药物组合物的用途，其中每个取代基如规范中定义。

  公开号：

  US20140171431A1

文献信息

• Higher order iminodiacetic acid libraries for probing protein–protein interactions
  作者：Dale L. Boger、Joel Goldberg、Weiqin Jiang、Wenying Chai、Pierre Ducray、Jae Kyoo Lee、Rachel S. Ozer、Carl-Magnus Andersson

  DOI：10.1016/s0968-0896(98)00128-x

  日期：1998.8

  Full details of the preparation of iminodiacetic acid diamide dimer (2040 compounds), trimer (560 compounds), and tetramer (1596 compounds) libraries by multistep convergent solution-phase synthesis for studying protein-protein interactions are provided. The libraries were assembled in a format providing small 8-10 compound mixtures and the deconvolution of many of the small mixtures to identify screening leads by resynthesis of the individual components have been conducted for 320 of the individual compounds to date. A representative example of the subsequent exploration of the structure-activity relationships for an identified receptor binding antagonist (200 additional individual compounds) and steps taken for potential elaboration to a receptor dimerization agonist are defined with preparation of representative linked dimers (70 compounds). (C) 1998 Elsevier Science Ltd. All rights reserved.
• AZOLE HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE
  申请人：Shen Jianhua

  公开号：US20140171431A1

  公开（公告）日：2014-06-19

  The present invention relates to the field of pharmaceutical chemistry, and in particular, to a novel class of azole compounds represented by general formula (I), (II) or (III) and a preparation method thereof, a pharmaceutical composition with the compounds as active components, and a use of the azole compounds and the pharmaceutical composition in the preparation of a medicament for treatment of diseases associated with Lp-PLA 2 enzyme activities, wherein each substituent is as defined in the specification.

  本发明涉及制药化学领域，特别是一种由通式（I）、（II）或（III）表示的新型类唑化合物，以及其制备方法，以这些化合物为活性成分的药物组合物，以及在制备用于治疗与Lp-PLA2酶活性相关疾病的药物中使用这些唑化合物和药物组合物的用途，其中每个取代基如规范中定义。