1-[3-bromo-5-(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)benzofuran-2-yl]cyclopentane carboxylic acid | 167984-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 1-[3-bromo-5-(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)benzofuran-2-yl]cyclopentane carboxylic acid
• 英文别名: 1-[3-Bromo-5-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-1-benzofuran-2-yl]cyclopentane-1-carboxylic acid
• CAS: 167984-60-3
• 化学式: C₂₅H₂₆BrN₃O₃
• 分子量: 496.404
• InChiKey: MZVWTYCGOWDCHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Method of treatment or prophylaxis
  申请人：Smith Therese Maree

  公开号：US20060223741A1

  公开（公告）日：2006-10-05

  The present invention is directed to methods and agents that are useful in the prevention and amelioration of signs and symptoms associated with neuropathic conditions. More particularly, the present invention discloses the use of angiotensin II receptor 2 (AT 2 receptor) antagonists for the treatment, prophylaxis, reversal and/or symptomatic relief of neuropathic pain, including mechanical hyperalgesia, thermal or mechanical allodynia, diabetic pain and entrapment pain, in vertebrate animals and particularly in human subjects. The AT 2 receptor antagonists may be provided alone or in combination with other compounds such as those that are useful in the control of neuropathic conditions.

  本发明涉及有助于预防和改善与神经病变相关的体征和症状的方法和制剂。更具体地说，本发明公开了血管紧张素 II 受体 2（AT 2 受体）拮抗剂用于治疗、预防、逆转和/或症状缓解脊椎动物，特别是人类受试者的神经性疼痛，包括机械性痛觉减退、热敏或机械异感、糖尿病痛和内陷痛。AT 2 受体拮抗剂可单独使用，也可与其他化合物（如有助于控制神经病理性症状的化合物）联合使用。
• METHOD OF TREATMENT OR PROPHYLAXIS
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：EP1830869A1

  公开（公告）日：2007-09-12
• METHOD OF TREATMENT OR PROPHYLAXIS INFLAMMATORY PAIN
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：EP1996183A1

  公开（公告）日：2008-12-03
• Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
  申请人：Biggs David Paul

  公开号：US20090177267A1

  公开（公告）日：2009-07-09

  This invention relates to medical devices and an angiotensin II type 2 (AT 2 ) receptor antagonist compound, the medical device being adapted to release the AT 2 receptor antagonist compound within a body of a patient. This invention also relates to medical devices and methods of treatment of disease, such as aneurysms and aortic dissection. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
• METHOD OF TREATMENT OR PROPHYLAXIS OF INFLAMMATORY PAIN
  申请人：Smith Maree Therese

  公开号：US20100292159A1

  公开（公告）日：2010-11-18

  This invention discloses the use of angiotensin II receptor 2 (AT 2 receptor) antagonists for the treatment, prophylaxis, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals and particularly in human subjects. The AT 2 receptor antagonists may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory conditions.