磷酸阿尼利定 | 4268-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 磷酸阿尼利定
• 英文名称: Anileridine Phosphate
• 英文别名: ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate;phosphoric acid
• CAS: 4268-37-5
• 化学式: C22H31N2O6P
• 分子量: 450.5
• InChiKey: FLQCEKVTYABVSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.48
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Drug delivery device for delivery of two or more independently user selectable multiple doses of medicaments with user operable variable dose locking mechanisms
  申请人：Wockhardt Limited

  公开号：US10376649B2

  公开（公告）日：2019-08-13

  It may be one of the aspects of the invention that a drug delivery device for delivery of two or more independently user selectable multiple doses of medicaments contained in separate cartridges of the medicament reservoirs within a single device operatively connected to a single dispense interface which may be operatively connected to a single activation button; It may be another aspect of the invention that unlocking of the user operable variable dose locking mechanism of the drug delivery device may be easily carried out by one hand operation by a lock slider unlock by the user.

  本发明的一个方面可能是，一种给药装置用于给药两个或多个独立的用户可选择的多剂量药剂，这些药剂分别装在单个装置内的药剂储藏盒中，该装置可操作地连接到单个给药接口，该接口可操作地连接到单个激活按钮；本发明的另一个方面可能是，用户可通过单手操作锁定滑块解锁给药装置的用户可操作可变剂量锁定机构。
• Combinatorial analysis and repair
  申请人：Pedersen Henrik

  公开号：US10722562B2

  公开（公告）日：2020-07-28

  A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit. The diagnosis and repair processes may involve chemical, physical, or mechanical means. The units being diagnosed and repaired include live matter (e.g. human beings, animals, plants) as well as non-live matter (e.g. buildings, electronic equipment, polymer materials).

  通过对不希望出现的状态进行特定诊断，并利用所述特定诊断作为以适当方式修复所述装置的手段，对装置进行适当修复的方法。诊断和修复过程可能涉及化学、物理或机械手段。被诊断和修复的单元包括活体（如人类、动物、植物）和非活体（如建筑物、电子设备、高分子材料）。
• Engineered receptor/ligand system for delivery of therapeutic agents
  申请人：University of Florida Research Foundation, Incorporated

  公开号：US11000597B2

  公开（公告）日：2021-05-11

  Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent to a subject utilizing an engineered receptor-ligand system, such as an engineered dockerin-cohesin system. As described herein, previously-developed targeted delivery systems for delivering therapeutic and diagnostic agents to a tissue of interest have drawbacks that have not been addressed to date. For example, with respect to the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB), both of which hamper delivery of agents to the brain, others have relied on the use of endogenously expressed receptors, like the transferrin receptor, to assist the agent across the barriers.

  本文提供了与利用工程受体-配体系统（如工程 dockerin-cohesin系统）向受试者靶向递送治疗剂或诊断剂有关的组合物和方法。如本文所述，以前开发的将治疗剂和诊断剂靶向输送到相关组织的靶向输送系统存在迄今尚未解决的缺点。例如，血脑屏障（BBB）和血-脑脊液屏障（BCSFB）都会阻碍将药剂输送到大脑，因此其他药物依赖于使用内源性表达的受体（如转铁蛋白受体）来帮助药剂穿过屏障。
• Salts of analgesic substances in oil, and methods of making and using the same
  申请人：——

  公开号：US20030069318A1

  公开（公告）日：2003-04-10

  The present invention relates in part to compositions comprising salts of an analgesic agent and an oil, and methods of using and making the same. In certain embodiments, the compositions may be used as part of a treatment regimen to alleviate pain.

  本发明部分涉及由镇痛剂盐类和油类组成的组合物，以及使用和制造这种组合物的方法。 在某些实施方案中，这些组合物可用作缓解疼痛的治疗方案的一部分。
• TRANSDERMAL DRUG DELIVERY FORMULATION
  申请人：Nuvo Research Inc.

  公开号：EP1909772A1

  公开（公告）日：2008-04-16