4-[6-amino-5-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]phenol | 1314882-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[6-amino-5-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]phenol
• CAS: 1314882-51-3
• 化学式: C₂₂H₂₄N₄O
• 分子量: 360.459
• InChiKey: JJIBPOFDJWBISC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  65.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NEW ANTI-MALARIAL AGENTS
  申请人：Witty Michael John

  公开号：US20120295905A1

  公开（公告）日：2012-11-22

  The present invention is related to a use of aminopyridine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyridine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

  本发明涉及氨基吡啶衍生物在制造预防或治疗疟疾药物方面的用途。具体而言，本发明涉及氨基吡啶衍生物，可用于制备制药配方，以抑制疟原虫的增殖。
• US9024033B2
  申请人：——

  公开号：US9024033B2

  公开（公告）日：2015-05-05
• [EN] NEW ANTI-MALARIAL AGENTS<br/>[FR] NOUVEAUX AGENTS ANTIPALUDIQUES
  申请人：MEDICINES FOR MALARIA VENTURE MMV

  公开号：WO2011086531A2

  公开（公告）日：2011-07-21

  The present invention is related to a use of aminopyridine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyridine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.