2,8-diamino-4,10-bis(4-chlorophenyl)-3,9-dicyano-4H,10H-chromeno[8,7-h]chromene | 130944-08-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 2,8-diamino-4,10-bis(4-chlorophenyl)-3,9-dicyano-4H,10H-chromeno[8,7-h]chromene
• 英文别名: 3,9-Diamino-1,7-bis(4-chlorophenyl)-1,7-dihydrochromeno[8,7-h]chromene-2,8-dicarbonitrile
• CAS: 130944-08-0
• 化学式: C₃₀H₁₈Cl₂N₄O₂
• 分子量: 537.405
• InChiKey: GPXSZDJQZQJXLH-UHFFFAOYSA-N

物化性质

• 熔点：
  320-321 °C (decomp)
• 沸点：
  791.3±60.0 °C(Predicted)
• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-氯苄亚基丙二腈 、 1,5-二羟基萘 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以86%的产率得到2,8-diamino-4,10-bis(4-chlorophenyl)-3,9-dicyano-4H,10H-chromeno[8,7-h]chromene
  参考文献：
  名称：

  Elagamey; El-Taweel, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 9, p. 885 - 886

  摘要：

  DOI：

文献信息

• Fibrous nanosilica spheres KCC-1@NH2 as highly effective and easily retrievable catalyst for the synthesis of chromenes
  作者：Hourieh Sadat Oboudatian、Javad Safaei-Ghomi

  DOI：10.1007/s11164-022-04695-9

  日期：2022.5

  A three-component reaction of naphthalene-1,5-diol, malononitrile and aromatic aldehydes has been achieved in the presence of fibrous nanosilica spheres KCC-1@NH2 as highly effective heterogeneous catalysts to produce of chromenes. In this study, simple and effective methods were used for the preparation of nanosilica spheres KCC-1@NH2 as basic catalysts. A fibrous surface morphology, high surface area, high mechanical stability, the easy separation of the nanocatalyst and the recyclability, nontoxicity, versatility, combined with low reaction times and excellent yields, make the present protocol very useful for the synthesis of the chromenes. The catalyst has been characterized by FT-IR, XRD, EDX, FE-SEM, TEM, BET and TGA. Also, the synthesized products were confirmed by 1H-NMR, 13C-NMR, FT-IR.

  在纤维状纳米二氧化硅球 KCC-1@NH2 作为高效异相催化剂存在下，实现了萘-1,5-二醇、丙二腈和芳香醛的三组分反应，生成了色烯。本研究采用简单有效的方法制备了作为碱性催化剂的纳米二氧化硅球 KCC-1@NH2。纤维状的表面形态、高比表面积、高机械稳定性、纳米催化剂的易分离性、可回收性、无毒性、多功能性，再加上反应时间短、收率高，使本方案非常适用于合成色烯。傅立叶变换红外光谱、XRD、EDX、FE-SEM、TEM、BET 和 TGA 对催化剂进行了表征。此外，还通过 1H-NMR、13C-NMR 和 FT-IR 对合成产物进行了确认。
• Synthesis of 2‐Aminochromene Derivatives Catalyzed by KF/Al₂O₃
  作者：Xiang‐shan Wang、Da‐qing Shi、Hui‐zhen Yu、Gao‐feng Wang、Shu‐jiang Tu

  DOI：10.1081/scc-120027291

  日期：2004.12.31

  A series of 2-aminochromene derivatives include 2-aminobenzo-[h]chromene and naphtha[1,2-b;6.5-b']dipyrans derivatives were synthesized from arylaidehyde, malononitrile or ethyl cyanoacetate, with 1-naphthol or 1,5-naphthalenediol in refluxing ethyl alcohol catalyzed by KF-Al2O3. The structure of the products was confirmed by X-ray analysis.
• ——
  作者：A. M. Shestopalov、Yu. M. Emelianova、V. N. Nesterov

  DOI：10.1023/a:1022135402451

  日期：——

  Substituted 2-aminochromenes were synthesized by three-component condensation of aromatic aldehydes, derivatives of cyanoacetic acid, and phenols or naphthols. The molecular and crystal structure of 2-amino-3-cyano-6-hydroxy-4-phenyl-4H-benzo[f]chromene was established by X-ray diffraction analysis.
• GHANI, ALI ELAGAMEY ABDEL;MOHAMED, ABDEL AZIZ FATHY EL-TAWEEL, INDIAN J. CHEM. B , 29,(1990) N, C. 885-886
  作者：GHANI, ALI ELAGAMEY ABDEL、MOHAMED, ABDEL AZIZ FATHY EL-TAWEEL

  DOI：——

  日期：——
• Elagamey; El-Taweel, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 9, p. 885 - 886
  作者：Elagamey、El-Taweel

  DOI：——

  日期：——