7,9-bis(4-methoxyphenyl)-6,6-dimethyl-1,2,4,8-tetraazaspiro[4.5]decane-3-thione | 1169662-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 7,9-bis(4-methoxyphenyl)-6,6-dimethyl-1,2,4,8-tetraazaspiro[4.5]decane-3-thione
• 英文别名: 7,9-bis(4-methoxyphenyl)-6,6-dimethyl-1,2,4,8-tetrazaspiro[4.5]decane-3-thione
• CAS: 1169662-60-5
• 化学式: C₂₂H₂₈N₄O₂S
• 分子量: 412.556
• InChiKey: ZBJHTEIEMLGXGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  r-2,c-6-bis(4-methoxyphenyl)-c-3,t-3-dimethylpiperidin-4-one 在 间氯过氧苯甲酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 7,9-bis(4-methoxyphenyl)-6,6-dimethyl-1,2,4,8-tetraazaspiro[4.5]decane-3-thione
  参考文献：
  名称：

  Solvent-free one-pot synthesis, characterization, antibacterial and antifungal activities of novel spiropiperidinyl-1,2,4-triazolidine-3-thiones

  摘要：

  A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, we tested all the synthesized compounds for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains.

  DOI：

  10.1007/s10593-011-0720-5

文献信息

• Solvent-free one-pot synthesis, characterization, antibacterial and antifungal activities of novel spiropiperidinyl-1,2,4-triazolidine-3-thiones
  作者：V. Kanagarajan、J. Thanusu、M. R. Ezhilarasi、M. Gopalakrishnan

  DOI：10.1007/s10593-011-0720-5

  日期：2011.4

  A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, we tested all the synthesized compounds for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains.