6-(2,6-dichlorophenyl)-8-methoxy-2-(3-methoxy-4-piperazinophenyl)aminopyrido[2,3-d]pyrimidin-7-one | 1021305-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-(2,6-dichlorophenyl)-8-methoxy-2-(3-methoxy-4-piperazinophenyl)aminopyrido[2,3-d]pyrimidin-7-one
• 英文别名: 6-(2,6-Dichlorophenyl)-8-methoxy-2-(3-methoxy-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one
• CAS: 1021305-10-1
• 化学式: C₂₅H₂₄Cl₂N₆O₃
• 分子量: 527.41
• InChiKey: SQHXONVOIHSFII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• PYRIDO Ý2, 3-D¨PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：GPC Biotech Inc.

  公开号：EP2084159A1

  公开（公告）日：2009-08-05
• PYRIDO [2,3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：Murthi Krisna

  公开号：US20110201594A1

  公开（公告）日：2011-08-18

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• Pyrido-[2,3-D] Pyrimidines and Their Use as Kinase Inhibitors
  申请人：MURTHI KRISHNA

  公开号：US20140163003A1

  公开（公告）日：2014-06-12

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• US8518958B2
  申请人：——

  公开号：US8518958B2

  公开（公告）日：2013-08-27
• [EN] PYRIDO [2, 3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS<br/>[FR] PYRIDO[2,3-D]PYRIMIDINES ET UTILISATION DE CELLES-CI EN TANT QU'INHIBITEURS DE KINASES
  申请人：GPC BIOTECH INC

  公开号：WO2008047307A1

  公开（公告）日：2008-04-24

  [EN] The present invention provides derivatives of pyrido [2,3-d]pyrimidin-7-one of formula (I). These compounds are kinase inhibitors, including compounds that show antiproliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
  [FR] La présente invention concerne des dérivés de pyrido[2,3-d]pyrimidin-7-one de formule (I). Ces composés sont des inhibiteurs de kinases, comprenant des composés qui présentent une activité antiproliférative, y compris contre des cellules tumorales, et ils sont utiles dans le traitement de maladies dont le cancer.