DMT(-3)2-deoxy-D-eryPenf5Cl(b)-uracil-1-yl | 219556-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: DMT(-3)2-deoxy-D-eryPenf5Cl(b)-uracil-1-yl
• 英文别名: 1-[(2R,4S,5S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(chloromethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 219556-71-5
• 化学式: C₃₀H₂₉ClN₂O₆
• 分子量: 549.023
• InChiKey: LXXUQOCBVYZDSY-ZRRKCSAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  86.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  DMT(-3)2-deoxy-D-eryPenf5Cl(b)-uracil-1-yl 在 四(三苯基膦)钯 copper(l) iodide 、 TEA 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 3-硝基-1,2,4-三氮唑 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 120.0h， 生成 2-[[1-[(2R,4S,5S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(chloromethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]amino]-N-[3-[1-[(2R,4S,5S)-5-(chloromethyl)-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-ynyl]acetamide
  参考文献：
  名称：

  Modified oligonucleotides with a 5′-5′ interbase semi-rigid junction for alternate strand triplex formation

  摘要：

  Solid-phase synthesis of 5'-5'-linked oligonucleotides with opposite polarities tethered via nucleic bases has been performed using a modified dinucleoside bearing an H-phosphonate group at the 3'-position of one nucleoside and a dimethoxytrityl group-at the 3'-position of the second nucleoside. This system is aimed at forming a base tetrad at the junction in order to provide better stabilization. The linker used between the two 5'-terminal bases in the same plane involves a triple bond in order to rigidify the junction. The two oligonucleotide :chains are either made of natural nucleosides or one of them is built With N3' -->P5' phosphoramidates. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02035-8
• 作为产物：
  描述：

  2-脱氧尿苷 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 、 四氯化碳 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 DMT(-3)2-deoxy-D-eryPenf5Cl(b)-uracil-1-yl
  参考文献：
  名称：

  Modified oligonucleotides with a 5′-5′ interbase semi-rigid junction for alternate strand triplex formation

  摘要：

  Solid-phase synthesis of 5'-5'-linked oligonucleotides with opposite polarities tethered via nucleic bases has been performed using a modified dinucleoside bearing an H-phosphonate group at the 3'-position of one nucleoside and a dimethoxytrityl group-at the 3'-position of the second nucleoside. This system is aimed at forming a base tetrad at the junction in order to provide better stabilization. The linker used between the two 5'-terminal bases in the same plane involves a triple bond in order to rigidify the junction. The two oligonucleotide :chains are either made of natural nucleosides or one of them is built With N3' -->P5' phosphoramidates. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02035-8