1-<(tert-butyldioxy)methyl>-4-methylpiperidine | 116466-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-<(tert-butyldioxy)methyl>-4-methylpiperidine
• 英文别名: 1-[(tert-butyldioxy)methyl]-4-methylpiperidine；1-t-Butyldioxymethyl-4-methylpiperidine；1-(tert-butylperoxymethyl)-4-methylpiperidine
• CAS: 116466-10-5
• 化学式: C₁₁H₂₃NO₂
• 分子量: 201.309
• InChiKey: FULMLZAHYNIOSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲基哌啶 、 叔丁基过氧化氢 、 聚合甲醛 以 甲醇 、 水 为溶剂， 反应 1.0h， 以98%的产率得到1-<(tert-butyldioxy)methyl>-4-methylpiperidine
  参考文献：
  名称：

  Amine peroxides as potential antimalarials

  摘要：

  Six model amine peroxides (4-9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.

  DOI：

  10.1021/jm00121a013

文献信息

• Amine peroxides as potential antimalarials
  作者：Jonathan L. Vennerstrom

  DOI：10.1021/jm00121a013

  日期：1989.1

  Six model amine peroxides (4-9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.