4-[1,1-Bis[4-hydroxy-3,5-bis[(4-methylpiperazin-1-yl)methyl]phenyl]ethyl]-2,6-bis[(4-methylpiperazin-1-yl)methyl]phenol | 1086840-22-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-[1,1-Bis[4-hydroxy-3,5-bis[(4-methylpiperazin-1-yl)methyl]phenyl]ethyl]-2,6-bis[(4-methylpiperazin-1-yl)methyl]phenol
• CAS: 1086840-22-3
• 化学式: C₅₆H₉₀N₁₂O₃
• 分子量: 979.409
• InChiKey: NCKAJSCWHCGWHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  71
• 可旋转键数：
  15
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  99.6
• 氢给体数：
  3
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 聚合甲醛 、 1,1,1-三(4-羟基苯基)乙烷 以 乙醇 、 水 为溶剂， 反应 7.0h， 以67%的产率得到4-[1,1-Bis[4-hydroxy-3,5-bis[(4-methylpiperazin-1-yl)methyl]phenyl]ethyl]-2,6-bis[(4-methylpiperazin-1-yl)methyl]phenol
  参考文献：
  名称：

  WO2008/149345

  摘要：

  公开号：

文献信息

• Tri-aryl compounds and compositions comprising the same
  申请人：Ben Gurion University of the Negev Research and Development Authority

  公开号：EP2152663B1

  公开（公告）日：2014-03-19
• COMPOUNDS FOR THE TREATMENT OF DIABETES AND DISEASE COMPLICATIONS ARISING FROM SAME
  申请人：Ben Gurion University of the Negev Research and Development Authority

  公开号：EP3065723B1

  公开（公告）日：2020-09-23
• TRI-ARYL COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME
  申请人：Priel Esther

  公开号：US20100256382A1

  公开（公告）日：2010-10-07

  The present invention relates to a novel class of tri-aryl compounds, compositions comprising the same and processes for the preparation thereof.
• TELOMERASE ACTIVATING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Gazit Aviv

  公开号：US20100267667A1

  公开（公告）日：2010-10-21

  The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
• Compounds for the Treatment of Diabetes and Disease Complications Arising from Same
  申请人：BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY

  公开号：US20160263124A1

  公开（公告）日：2016-09-15

  The present invention is directed to use of a series of tri-aryl compounds and compositions comprising the same for the treatment of diabetes and disease conditions arising as a consequence of the same.