(3R,7S,8aR)-7-ethyl-5-oxo-3,8a-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine | 1049705-11-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,7S,8aR)-7-ethyl-5-oxo-3,8a-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
• CAS: 1049705-11-4
• 化学式: C₂₁H₂₃NO₂
• 分子量: 321.419
• InChiKey: YQHGKGLSTAMXCY-LKUPVBHCSA-N

反应信息

• 作为产物：
  描述：

  (3R,8aR)-6-(benzyloxycarbonyl)-5-oxo-3,8a-diphenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 在 palladium on activated charcoal ammonium formate 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 30.0h， 生成 (3R,7S,8aR)-7-ethyl-5-oxo-3,8a-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 、 (3R,7R,8aR)-7-ethyl-5-oxo-3,8a-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
  参考文献：
  名称：

  An Enantioselective Synthetic Route to cis-2,4-Disubstituted and 2,4-Bridged Piperidines

  摘要：

  A synthetic route to enantiopure cis-2,4-disubstituted and 2,4-bridged piperidines is reported, the key step being a stereoselective conjugate addition of an organocuprate to a phenylglycinol-derived unsaturated lactam bearing a substituent at the 8a-position.

  DOI：

  10.1021/jo801172b