(S)-1-[(1-triphenylmethyl)-imidazol-2-yl]-propan-2-ol | 189948-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (S)-1-[(1-triphenylmethyl)-imidazol-2-yl]-propan-2-ol
• 英文别名: (2S)-1-(1-tritylimidazol-2-yl)propan-2-ol
• CAS: 189948-97-8
• 化学式: C₂₅H₂₄N₂O
• 分子量: 368.478
• InChiKey: HFAHQXAHVYYUIH-FQEVSTJZSA-N

物化性质

• 沸点：
  497.0±33.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-1-[(1-triphenylmethyl)-imidazol-2-yl]-propan-2-ol 在 溶剂黄146 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.5h， 生成 1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-((S)-6-methyl-6,7-dihydro-5-oxa-1,3a-diaza-4-phospha-inden-4-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Imidazo-oxazaphosphorines as Precursors to Chiral Phosphite Triesters

  摘要：

  New bicyclic imidazo-oxazaphosphorines underwent a highly diastereoselective displacement of the imidazole moiety upon reaction with various alcohols, leading to chiral phosphite triesters as single diastereomers. The introduction of a nucleoside on this bicyclic structure was investigated by several routes, leading to new nucleoside building blocks.

  DOI：

  10.1080/07328319808003465
• 作为产物：
  描述：

  N-三苯甲基咪唑 、 S-环氧丙烷 在 正丁基锂 作用下， 生成 (S)-1-[(1-triphenylmethyl)-imidazol-2-yl]-propan-2-ol
  参考文献：
  名称：

  Imidazo-oxazaphosphorines as Precursors to Chiral Phosphite Triesters

  摘要：

  New bicyclic imidazo-oxazaphosphorines underwent a highly diastereoselective displacement of the imidazole moiety upon reaction with various alcohols, leading to chiral phosphite triesters as single diastereomers. The introduction of a nucleoside on this bicyclic structure was investigated by several routes, leading to new nucleoside building blocks.

  DOI：

  10.1080/07328319808003465