(R)-1-(4-methylphenyl)dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-dione | 1020410-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-1-(4-methylphenyl)dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-dione
• 英文别名: (7aR)-1-(4-methylphenyl)-3,6,7,7a-tetrahydropyrrolo[1,2-a]imidazole-2,5-dione
• CAS: 1020410-90-5
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: IABKCVSRMMSOMZ-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
  申请人：NIKEM RESEARCH S.R.L.

  公开号：EP1925304A1

  公开（公告）日：2008-05-28

  The use of a compound of formula (I) is disclosed in treating and/or preventing chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.

  本发明公开了式（I）化合物在治疗和/或预防化疗诱导的周围神经毒性（CIPN）中的用途。本发明包括药物组合物，其中式（I）化合物与抗癌剂混合存在。本发明还提供了一种可减少 CIPN 相关副作用的改良抗癌疗法。
• PYRROLOY[1,2-A]IMIDAZOLEDIONE EFFECTIVE IN THE TREATMENT OF PERIPHERAL NEUROTOXICITY INDUCED BY CHEMOTHERAPEUTIC AGENTS
  申请人：Neurotune AG

  公开号：EP2094265A1

  公开（公告）日：2009-09-02
• PYRROLO[1,2-A]IMIDAZOLEDIONE EFFECTIVE IN THE TREATMENT OF PERIPHERAL NEUROTOXICITY INDUCED BY CHEMOTHERAPEUTIC AGENTS
  申请人：Farina Carlo

  公开号：US20100062077A1

  公开（公告）日：2010-03-11

  The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.
• US7973066B2
  申请人：——

  公开号：US7973066B2

  公开（公告）日：2011-07-05
• [EN] PYRROLO[1,2-A]IMIDAZOLEDIONE EFFECTIVE IN THE TREATMENT OF PERIPHERAL NEUROTOXICITY INDUCED BY CHEMOTHERAPEUTIC AGENTS<br/>[FR] PYRROLO[1,2-A]IMIDAZOLÉDIONE EFFICACE DANS LE TRAITEMENT DE LA NEUROTOXICITÉ PÉRIPHÉRIQUE INDUITE PAR DES AGENTS CHIMIOTHÉRAPEUTIQUES
  申请人：BRANE DISCOVERY S R L

  公开号：WO2008058988A1

  公开（公告）日：2008-05-22

  [EN] The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.
  [FR] La présente invention concerne l'utilisation d'un composé de formule (I) capable de traiter et/ou de prévenir la neurotoxicité périphérique induite par la chimiothérapie (CIPN). L'invention inclut des compositions pharmaceutiques contenant le composé de formule (I) dans un mélange avec des agents anticancéreux. L'invention concerne également un traitement anticancéreux amélioré avec des effets secondaires CIPN réduits.