[3-(4-Phenylpiperazin-1-yl)cyclobutyl] methanesulfonate | 863644-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [3-(4-Phenylpiperazin-1-yl)cyclobutyl] methanesulfonate
• CAS: 863644-10-4
• 化学式: C₁₅H₂₂N₂O₃S
• 分子量: 310.417
• InChiKey: KIIMZVAWGQYZBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Catalytic Radiofluorination
  申请人：Elmaleh David R.

  公开号：US20100215578A1

  公开（公告）日：2010-08-26

  One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.

  本发明的一个方面涉及制备放射性氟代取代烷基、环烷基、芳基和烯基化合物的方法。在一个优选实施例中，使用氟化钾-18。本发明的另一个方面涉及含氟-18的哌嗪化合物，其作为成像剂有用。在某些实施例中，哌嗪化合物含有季铵胺基。本发明的另一个方面涉及含氟-18的芳基膦盐化合物，其作为成像剂有用。在某些实施例中，磷膦化合物是四芳基膦盐。本发明的另一个方面涉及一种获得哺乳动物正电子发射图像的方法，包括以下步骤：向哺乳动物注射本发明的化合物，并获取哺乳动物的正电子发射光谱。
• CATALYTIC RADIOFLUORINATION
  申请人：Elmaleh David R.

  公开号：US20120207677A1

  公开（公告）日：2012-08-16

  One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.

  本发明的一个方面涉及制备放射性氟代取代烷基、环烷基、芳基和烯基化合物的方法。在优选实施例中，使用氟化钾-18。本发明的另一个方面涉及含氟-18的芳基铵化合物，其可用作成像剂。在某些实施例中，铵化合物是四芳基铵盐。本发明的另一个方面涉及含氟-18的芳基磺酸盐化合物，其可用作成像剂。在某些实施例中，磺酸盐化合物是三芳基磺酸盐。本发明的另一个方面涉及一种获取哺乳动物正电子发射图像的方法，包括向哺乳动物给予本发明的化合物，并获取哺乳动物的正电子发射光谱。
• Catalytic radiofluorination
  申请人：The General Hospital Corporation

  公开号：EP2610234A1

  公开（公告）日：2013-07-03

  One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.

  本发明的一个方面涉及一种制备放射性氟取代的烷基、环烷基、芳基和烯基化合物的方法。在一个优选的实施方案中，使用的是氟化钾-18。本发明的另一方面涉及可用作成像剂的含氟-18 的哌嗪化合物。在某些实施方案中，哌嗪化合物含有季胺。本发明的另一方面涉及可用作成像剂的含氟-18 的芳基膦化合物。在某些实施方案中，鏻化合物是四芳基鏻盐。本发明的另一方面涉及一种获得哺乳动物正电子发射图像的方法，包括以下步骤：向哺乳动物施用本发明的化合物，并获得哺乳动物的正电子发射光谱。
• US7632485B2
  申请人：——

  公开号：US7632485B2

  公开（公告）日：2009-12-15
• US8257680B1
  申请人：——

  公开号：US8257680B1

  公开（公告）日：2012-09-04