methyl 2-[(benzyloxycarbonyl)amino]-2-deoxy-4,6-isopropylidene-3-O-tetradecanoyl-α-D-glucopyranoside | 470665-48-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: methyl 2-[(benzyloxycarbonyl)amino]-2-deoxy-4,6-isopropylidene-3-O-tetradecanoyl-α-D-glucopyranoside
• CAS: 470665-48-6
• 化学式: C₃₂H₅₁NO₈
• 分子量: 577.759
• InChiKey: OZRYZKUXUTZMTL-JXQOEZKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.42
• 重原子数：
  41.0
• 可旋转键数：
  17.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  101.55
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  methyl 2-[(benzyloxycarbonyl)amino]-2-deoxy-4,6-isopropylidene-3-O-tetradecanoyl-α-D-glucopyranoside 在 palladium on activated charcoal benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 氢气 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 67.0h， 生成 methyl 2-[(6-benzyloxycarbonylamino)hexanoyl]amino-2-deoxy-4,6-isopropylidene-3-O-tetradecanoyl-α-D-glucopyranoside
  参考文献：
  名称：

  SYNTHESIS OF PSEUDO-DISACCHARIDE ANALOGUES OF LIPID A: HAPTENS FOR THE GENERATION OF ANTIBODIES WITH GLYCOSIDASE ACTIVITY TOWARDS LIPID A

  摘要：

  In order to develop a generic treatment of sepsis caused by infections with Gram-negative bacteria, a series of pseudo-disaccharide analogues of lipid A (1-5) was synthesized. These adducts not only harbor a 2-acylaminodideoxynojirimycin unit mimicking the transition state of the,glycosidic hydrolysis, but also a 2-N, 3-O-diacylated glucosamine moiety capable of generating catalytic antibodies with more selective glycosidase properties towards lipid A.

  DOI：

  10.1081/car-120004331
• 作为产物：
  描述：

  ((2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yl)-carbamic acid benzyl ester 在 4-二甲氨基吡啶 、 对甲苯磺酸 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 34.0h， 生成 methyl 2-[(benzyloxycarbonyl)amino]-2-deoxy-4,6-isopropylidene-3-O-tetradecanoyl-α-D-glucopyranoside
  参考文献：
  名称：

  SYNTHESIS OF PSEUDO-DISACCHARIDE ANALOGUES OF LIPID A: HAPTENS FOR THE GENERATION OF ANTIBODIES WITH GLYCOSIDASE ACTIVITY TOWARDS LIPID A

  摘要：

  In order to develop a generic treatment of sepsis caused by infections with Gram-negative bacteria, a series of pseudo-disaccharide analogues of lipid A (1-5) was synthesized. These adducts not only harbor a 2-acylaminodideoxynojirimycin unit mimicking the transition state of the,glycosidic hydrolysis, but also a 2-N, 3-O-diacylated glucosamine moiety capable of generating catalytic antibodies with more selective glycosidase properties towards lipid A.

  DOI：

  10.1081/car-120004331