1-Methyl-2-phenyl-1-aza-cycloheptan | 1133-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: 1-Methyl-2-phenyl-1-aza-cycloheptan
• 英文别名: 1-Methyl-2-phenylazepane
• CAS: 1133-67-1
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: RJJRKJKPLQICGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Methyl-2-phenyl-1-aza-cycloheptan 、 乙酸酐 在 溶剂黄146 作用下， 生成 1-Acetoxy-6-(acetylmethylamino)-1-phenyl-hexan
  参考文献：
  名称：

  Gol'dfarb,Ya.L. et al., Journal of general chemistry of the USSR, 1969, vol. 39, p. 1071 - 1075

  摘要：

  DOI：
• 作为产物：
  描述：

  反-N-甲基-6-苯基-5-己烯-1-胺 以 乙腈 为溶剂， 以82%的产率得到2-苄基-1-甲基哌啶
  参考文献：
  名称：

  分子内苯乙烯-胺激发复合物的光物理和光化学行为

  摘要：

  研究了一系列仲和叔 ω-(β-苯乙烯基) 氨基烷烃的光物理和光化学行为，其中 1 到 5 个亚甲基将苯乙烯基和氨基分开，并与 1-苯基丙烯与仲胺和叔胺的分子间反应进行了比较。根据涉及单线态激基复合物和双自由基中间体的机制讨论了聚亚甲基链长、溶剂极性、温度和 N-烷基的体积对产物产率和比率的影响

  DOI：

  10.1021/ja00009a041

文献信息

• Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome and Related Disorders
  申请人：Webster Scott Peter

  公开号：US20120095046A1

  公开（公告）日：2012-04-19

  The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-isothiazole compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

  本发明一般涉及治疗化合物领域。更具体地，本发明涉及某些酰胺异噻唑化合物，其在其他方面抑制11β-羟基类固醇脱氢酶1型（11β-HSD1）。本发明还涉及包括这些化合物的制药组合物，并且在体内外使用这些化合物和组合物以抑制11β-羟基类固醇脱氢酶1型；治疗通过抑制11β-羟基类固醇脱氢酶1型改善的疾病；治疗代谢综合症，包括2型糖尿病和肥胖症，以及相关疾病，包括胰岛素抵抗、高血压、脂质代谢紊乱和缺血性（冠状动脉）心脏病等；治疗中枢神经系统疾病，如轻度认知障碍和早期痴呆，包括阿尔茨海默病等。
• Amido-Thiophene Compounds and Their Use as 11-Beta-HSD1 Inhibitors
  申请人：Webster Scott Peter

  公开号：US20100267696A1

  公开（公告）日：2010-10-21

  The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

  本发明涉及治疗化合物领域。更具体地，本发明涉及某些酰胺噻吩化合物，其中包括抑制11β-羟基类固醇脱氢酶1型（11β-HSD1）的化合物。本发明还涉及包含这种化合物的制药组合物，以及在体内外使用这种化合物和组合物来抑制11β-羟基类固醇脱氢酶1型，治疗通过抑制11β-羟基类固醇脱氢酶1型改善的疾病，治疗代谢综合征，包括2型糖尿病和肥胖症，以及相关疾病，包括胰岛素抵抗、高血压、脂质异常和缺血性（冠状动脉）心脏病；治疗中枢神经系统疾病，如轻度认知障碍和早期痴呆，包括阿尔茨海默病等。
• Amido-Thiophene Compounds and Their Use
  申请人：Webster Scott Peter

  公开号：US20130012545A1

  公开（公告）日：2013-01-10

  The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

  本发明通常涉及治疗化合物领域。更具体地，本发明涉及某些酰胺噻吩化合物，其在其他方面抑制11β-羟化固醇脱氢酶1型（11β-HSD1）。本发明还涉及包括这些化合物的制药组合物，并且在体内外使用这些化合物和组合物来抑制11β-羟化固醇脱氢酶1型；治疗通过抑制11β-羟化固醇脱氢酶1型改善的疾病；治疗代谢综合征，包括2型糖尿病和肥胖症等疾病，以及相关疾病，包括胰岛素抵抗、高血压、脂质代谢紊乱和缺血性（冠状动脉）心脏病等心血管疾病；治疗CNS疾病，如轻度认知障碍和早期痴呆，包括阿尔茨海默病等。
• Inhibitors of Ion Channels
  申请人：Marron Brian Edward

  公开号：US20130072471A1

  公开（公告）日：2013-03-21

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  本发明提供了在通过抑制电压门控钠通道中的钠离子流来治疗疾病方面有用的化合物、组合物和方法。更具体地，本发明提供了取代芳基磺酰胺、包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或外周神经系统疾病，特别是疼痛和慢性疼痛的方法，通过阻断与所示条件的发生或复发相关的钠通道来实现。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道中的离子流来治疗神经病性或炎症性疼痛。
• Heterocyclic compounds and their production
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0503958A2

  公开（公告）日：1992-09-16

  Heterocyclic compounds selected from the group consisting of the compounds [IV] to [VII], [IX] and [X]. The heterocyclic compounds are useful for reactive materials in chemical industry and a process for producing the heterocyclic compounds.

  从化合物[IV]至[VII]、[IX]和[X]组成的组中选出的杂环化合物。这些杂环化合物可用作化学工业中的反应材料，也可用于杂环化合物的生产工艺。