4-[8-[3-chloro-4-(4-ethylpiperazin-1-yl)anilino]imidazo[1,2-a]pyridin-5-yl]-1H-pyridin-2-one | 1031285-86-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[8-[3-chloro-4-(4-ethylpiperazin-1-yl)anilino]imidazo[1,2-a]pyridin-5-yl]-1H-pyridin-2-one
• CAS: 1031285-86-5
• 化学式: C₂₄H₂₅ClN₆O
• 分子量: 448.955
• InChiKey: ISAORCOCSOVTJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases
  申请人：Edwards Paul John

  公开号：US20090048245A1

  公开（公告）日：2009-02-19

  Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

  本发明揭示了一种具有以下公式表示的新型咪唑吡啶化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物，包括人类的多种病症，包括但不限于ECM降解、关节降解和/或炎症等。
• IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：EDWARDS Paul John

  公开号：US20120010206A1

  公开（公告）日：2012-01-12

  Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

  本发明揭示了一种具有以下公式表示的新型咪唑吡啶化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于ECM降解，关节降解和/或炎症等。
• US7951818B2
  申请人：——

  公开号：US7951818B2

  公开（公告）日：2011-05-31