3-(5-Methylidene-2,6-dioxopiperidin-3-yl)propanamide | 141263-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(5-Methylidene-2,6-dioxopiperidin-3-yl)propanamide
• 英文别名: 3-(5-methylidene-2,6-dioxopiperidin-3-yl)propanamide
• CAS: 141263-75-4
• 化学式: C₉H₁₂N₂O₃
• 分子量: 196.206
• InChiKey: MGHSCHUCABQEGM-UHFFFAOYSA-N

物化性质

• 沸点：
  494.4±37.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  89.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 3-[2,6-dioxo-5-(triphenyl-λ5-phosphanylidene)piperidin-3-yl]propanamide 以 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以71%的产率得到3-(5-Methylidene-2,6-dioxopiperidin-3-yl)propanamide
  参考文献：
  名称：

  New phosphonium ylides by functionalization of triphenylphosphoranylideneacetamide

  摘要：

  Triphenylphosphoranylideneacetamide undergoes Michael reactions with several acceptors, giving rise, apart from the normal Michael adducts, to the formation of different products like glutarimide ylides and stabilized iminophosphoranes. Wittig reactions with these new ylides lead to a variety of alpha,beta-unsaturated carbonyl compounds.

  DOI：

  10.1016/s0040-4039(00)91662-9

文献信息

• New phosphonium ylides by functionalization of triphenylphosphoranylideneacetamide
  作者：Martin J. Wanner、Gerrit-Jan Koomen

  DOI：10.1016/s0040-4039(00)91662-9

  日期：1992.3

  Triphenylphosphoranylideneacetamide undergoes Michael reactions with several acceptors, giving rise, apart from the normal Michael adducts, to the formation of different products like glutarimide ylides and stabilized iminophosphoranes. Wittig reactions with these new ylides lead to a variety of alpha,beta-unsaturated carbonyl compounds.