2-Methyl-4,5-trimethylen-Δ²-thiazolin | 23185-13-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-Methyl-4,5-trimethylen-Δ²-thiazolin
• 英文别名: 2-methyl-4,5,6,6a-tetrahydro-3aH-cyclopentathiazole；2-methyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]thiazole
• CAS: 23185-13-9
• 化学式: C₇H₁₁NS
• 分子量: 141.237
• InChiKey: DRCRIZSZEZRKNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环戊烯 、 乙腈 生成 2-Methyl-4,5-trimethylen-Δ²-thiazolin
  参考文献：
  名称：

  Beger,J. et al., Journal fur praktische Chemie (Leipzig 1954), 1969, vol. 311, p. 408 - 419

  摘要：

  DOI：

文献信息

• TYK2 INHIBITORS AND USES THEREOF
  申请人：Nimbus Lakshmi, Inc.

  公开号：US20170066763A1

  公开（公告）日：2017-03-09

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
• HETEROBICYCLO-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170197991A1

  公开（公告）日：2017-07-13

  Disclosed are compounds of Formula G1: where “R G3 ”. “R d1 ” to “R d4 ”, “n”, “m”, “p”, “W”, “X”, “Y”, and “Z” are defined herein, which compounds are antagonists of A 2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A 2A receptor in the potential treatment or prevention of neurological disorders and diseases in which A 2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.