8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane | 795313-25-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane
• CAS: 795313-25-6
• 化学式: C14H19Cl2N2+
• 分子量: 286.2
• InChiKey: KVWIGOGQGWFTHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Process for the preparation of carbostyril derivatives, such as aripiprazole and its intermediates
  申请人：Salama Paul

  公开号：US20070032651A1

  公开（公告）日：2007-02-08

  A process for preparing carbostyril derivatives such as aripiprazole is described. Dichlorophenylpiperazine or an acid addition salt thereof is reacted with a compound of formula X—C 4 H 8 —Y or X—C 4 H 6 —Y to produce a novel quaternary spiro ammonium salt intermediate which is optionally isolated and purified. The quaternary spiro ammonium salt intermediate is reacted with 7-hydroxydihydrocarboxystyryl to produce the carbostyril derivative.

  描述了一种制备类似ariipiprazole的carbostyril衍生物的过程。将二氯苯基哌嗪或其酸加成盐与式为X-C4H8-Y或X-C4H6-Y的化合物反应，生成一种新的四元螺环铵盐中间体，该中间体可选择性地被分离和纯化。四元螺环铵盐中间体与7-羟基二氢羧基苯乙烯反应，生成carbostyril衍生物。
• Improved Process for the Preparation of Aripiprazole with Reduced Particle Size
  申请人：RAO Davuluri Ramamohan

  公开号：US20180155290A1

  公开（公告）日：2018-06-07

  The present invention relates to process for preparation of Aripiprazole with reduced particle size having dehydro impurity less than 0.1%.