1-cyclodecyl-piperidin-4-one | 252284-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-cyclodecyl-piperidin-4-one
• 英文别名: 1-cyclodecylpiperidin-4-one
• CAS: 252284-93-8
• 化学式: C₁₅H₂₇NO
• 分子量: 237.385
• InChiKey: BWTZWTCNBBJWIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环癸胺 、 potassium carbonate 、 1-乙基-1-甲基-4-氧代哌啶-1-碘化物 、 碳酸氢钠 、 在 乙酸乙酯 、 magnesium sulfate 、 silica gel 作用下， 以 乙醇 、 水 为溶剂， 反应 1.67h， 以Column chromatography on silica gel (toluene/ethylacetate 2:1) yielded the title compound (8.8 g, 85%) as a pale brown oil, MS的产率得到1-cyclodecyl-piperidin-4-one
  参考文献：
  名称：

  Spiro[piperidine-4,1'-pyrrolo [3,4-C] pyrrole]derivatives

  摘要：

  本发明涉及一般式化合物，其中R.sup.1为C.sub.5-12-环烷基，可选地被低碳烷基取代;十氢萘-1-基;十氢萘-2-基;茚-1-基或茚-2-基，可选地被低碳烷基取代;十氢萜烯-2-基;双环[6.2.0]癸-9-基;芴-1-基;双环[3.3.1]壬-9-基;2,3-二氢-1H-苯并-1-基;2,3,3a,4,5,6-六氢-1H-苯并-1-基;八氢茚-2-基;1,2,3,4-四氢萘-1-基;1,2,3,4-四氢萘-2-基;萘-低碳烷基-1-基;萘-低碳烷基-2-基;芴-1-基;和5-异丙基-2-甲基-双环[3.1.0]己-3-基; R.sup.2，R.sup.3为氢;羟基;低碳烷基; .dbd.O;或苯基，可选地被低烯丙基，卤素或烷氧基取代;R.sup.4为氢;低碳烷基;--(CH.sub.2).sub.n CH(OH)CF.sub.3;--(CH.sub.2).sub.n C.sub.3-6-环烷基;苯基;苄基;四氢呋喃-3-基;--(CH.sub.2).sub.n OCH.sub.2 C.sub.6 H.sub.5;--(CH.sub.2).sub.n 嘧啶基;3-甲基-噁唑-3-基-甲基;--(CH.sub.2).sub.n CH.sub.2 OH;--S(O).sub.2-低碳烷基;--C(O)-低碳烷基;--C(O)CF.sub.3;--C(O)(CH.sub.2).sub.n OCH.sub.3;--(CH.sub.2).sub.n C(O)N(低碳烷基).sub.2;--S(O).sub.2杂环芳基;--C(O)杂环芳基;--S(O).sub.2-苯基;--S(O).sub.2--N(低碳烷基).sub.2;--C(O)--C.sub.3-6-环烷基;--C(O)O-苯基;或--C(O)O-低碳烷基: R.sup.5为氢;卤素;低碳烷基;三氟甲基或低碳基氧基; n为0-3;以及其药学上可接受的酸加盐。公式I的化合物及其盐在治疗精神病学、神经学和生理学疾病中有用。

  公开号：

  US06075034A1

文献信息

• PREPARATION PROCESS OF PERFLUOROALKYL COMPOUND WITH MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL
  申请人：KANTO DENKA KOGYO CO., LTD.

  公开号：US20190169107A1

  公开（公告）日：2019-06-06

  A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound being an important intermediate of organic electronic materials, medicine, agricultural chemicals, functional polymer materials and the like. With monohydroperfluoroalkane is reacted a base and then a carbonyl compound to produce an alcohol having a perfluoroalkyl group. For example, potassium hydroxide is made to interact with trifluoromethane, and a reaction with a carbonyl compound is induced to produce an alcohol having a trifluoromethyl group.

  提供了一种简单的生产过程，使用单羟基全氟烷作为起始物质来制备全氟烷基化合物，该全氟烷基化合物是有机电子材料、药物、农药、功能性聚合物材料等的重要中间体。使用单羟基全氟烷与碱反应，再与羰基化合物反应，可以产生具有全氟烷基的醇。例如，可以将氢氧化钾与三氟甲烷相互作用，并诱导与羰基化合物反应，以产生具有三氟甲基基团的醇。
• Spiro[piperidine-4,1'-pyrrolo [3,4-C] pyrrole]derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US06075034A1

  公开（公告）日：2000-06-13

  The present invention relates to compounds of the general formula wherein R.sup.1 is C.sub.5-12 -cycloalkyl, optionally substituted by lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl; octahydro-inden-2-yl; 1,2,3,4-tetrahydro-naphthalen-1-yl; 1,2,3,4-tetrahydro-naphthalen-2-yl; naphthalen-lower alkyl-1-yl; naphthalen-lower alkyl-2-yl; acenaphthen-1-yl; and 5-isopropyl-2-methyl-bicyclo[3.1.0]hex-3-yl; R.sup.2, R.sup.3 are hydrogen; hydroxy; lower alkyl; .dbd.O; or phenyl, optionally substituted by lower allyl, halogen or alkoxy; R.sup.4 is hydrogen; lower alkyl; --(CH.sub.2).sub.n CH(OH)CF.sub.3 ; --(CH.sub.2).sub.n C.sub.3-6 -cycloalkyl; phenyl; benzyl; tetrahydrofuran-3-yl; --(CH.sub.2).sub.n OCH.sub.2 C.sub.6 H.sub.5 ; --(CH.sub.2).sub.n morpholinyl; 3-methyl-oxetan-3-yl-methyl; --(CH.sub.2).sub.n CH.sub.2 OH; --S(O).sub.2 -lower alkyl; --C(O)-lower alkyl; --C(O)CF.sub.3 ; --C(O)(CH.sub.2).sub.n OCH.sub.3 ; --(CH.sub.2).sub.n C(O)N(lower alkyl).sub.2 ; --S(O).sub.2 heteroaryl; --C(O)heteroaryl; --S(O).sub.2 -phenyl; --S(O).sub.2 --N(lower alkyl).sub.2 ; --C(O)--C.sub.3-6 -cycloalkyl; --C(O)O-phenyl; or --C(O)O-lower alkyl: R.sup.5 is hydrogen; halogen; lower alkyl; trifluoromethyl or lower alkoxy; n is 0-3; and to pharmaceutically acceptable acid addition salts thereof The compounds of formula I and their salts are useful as in the treatment of psychiatric, neurological and physiological disorders.

  本发明涉及一般式化合物，其中R.sup.1为C.sub.5-12-环烷基，可选地被低碳烷基取代;十氢萘-1-基;十氢萘-2-基;茚-1-基或茚-2-基，可选地被低碳烷基取代;十氢萜烯-2-基;双环[6.2.0]癸-9-基;芴-1-基;双环[3.3.1]壬-9-基;2,3-二氢-1H-苯并-1-基;2,3,3a,4,5,6-六氢-1H-苯并-1-基;八氢茚-2-基;1,2,3,4-四氢萘-1-基;1,2,3,4-四氢萘-2-基;萘-低碳烷基-1-基;萘-低碳烷基-2-基;芴-1-基;和5-异丙基-2-甲基-双环[3.1.0]己-3-基; R.sup.2，R.sup.3为氢;羟基;低碳烷基; .dbd.O;或苯基，可选地被低烯丙基，卤素或烷氧基取代;R.sup.4为氢;低碳烷基;--(CH.sub.2).sub.n CH(OH)CF.sub.3;--(CH.sub.2).sub.n C.sub.3-6-环烷基;苯基;苄基;四氢呋喃-3-基;--(CH.sub.2).sub.n OCH.sub.2 C.sub.6 H.sub.5;--(CH.sub.2).sub.n 嘧啶基;3-甲基-噁唑-3-基-甲基;--(CH.sub.2).sub.n CH.sub.2 OH;--S(O).sub.2-低碳烷基;--C(O)-低碳烷基;--C(O)CF.sub.3;--C(O)(CH.sub.2).sub.n OCH.sub.3;--(CH.sub.2).sub.n C(O)N(低碳烷基).sub.2;--S(O).sub.2杂环芳基;--C(O)杂环芳基;--S(O).sub.2-苯基;--S(O).sub.2--N(低碳烷基).sub.2;--C(O)--C.sub.3-6-环烷基;--C(O)O-苯基;或--C(O)O-低碳烷基: R.sup.5为氢;卤素;低碳烷基;三氟甲基或低碳基氧基; n为0-3;以及其药学上可接受的酸加盐。公式I的化合物及其盐在治疗精神病学、神经学和生理学疾病中有用。
• Spiro(piperidine-4,1'-pyrrolo(3,4-c)pyrrole)
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0963987A2

  公开（公告）日：1999-12-15

  The present invention relates to compounds of the general formula    wherein the substituents are described in the application and to pharmaceutically acceptable acid addition salts thereof. The compound of the invention are useful in the treatment of diseases related to the orphanin FQ (OFQ) receptor, which include psychiatric, neurological and physiological disorders, such as anxiety and stress disorders, depression, trauma, memory loss due to Alzheimer's disease or other dementias, deficits in cognition and leaning, epilepsy and convulsions, acute and/or chronic pain conditions, and symptoms of addictive drug withdrawal, control of water balance, Na+ excretion, arterial blood pressure disorders and metabolic disorders such as obesity.

  本发明涉及通式为 其中的取代基见本申请所述，以及其药学上可接受的酸加成盐。 本发明的化合物可用于治疗与孤儿素 FQ（OFQ）受体有关的疾病，这些疾病包括精神、神经和生理疾病，如焦虑和应激障碍、抑郁症、创伤、阿尔茨海默病或其他痴呆症导致的记忆丧失、认知和精益功能障碍、癫痫和抽搐、急性和/或慢性疼痛病症、成瘾性药物戒断症状、水平衡控制、Na+排泄、动脉血压紊乱和代谢紊乱，如肥胖。
• METHOD FOR PRODUCING PERFLUOROALKYL COMPOUND USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL
  申请人：Kanto Denka Kogyo Co., Ltd.

  公开号：EP3495341A1

  公开（公告）日：2019-06-12

  A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound being an important intermediate of organic electronic materials, medicine, agricultural chemicals, functional polymer materials and the like. With monohydroperfluoroalkane is reacted a base and then a carbonyl compound to produce an alcohol having a perfluoroalkyl group. For example, potassium hydroxide is made to interact with trifluoromethane, and a reaction with a carbonyl compound is induced to produce an alcohol having a trifluoromethyl group.

  提供了一种以单氢全氟烷烃为起始原料的全氟烷基化合物的简单生产工艺，全氟烷基化合物是有机电子材料、医药、农药、功能聚合物材料等的重要中间体。将单氢全氟烷烃与碱反应，然后与羰基化合物反应，生成具有全氟烷基的醇。例如，氢氧化钾与三氟甲烷发生作用，然后与羰基化合物发生反应，生成具有三氟甲基的醇。
• Preparation process of perfluoroalkyl compound with monohydroperfluoroalkane as starting material
  申请人：KANTO DENKA KOGYO CO., LTD.

  公开号：US10450253B2

  公开（公告）日：2019-10-22

  A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound being an important intermediate of organic electronic materials, medicine, agricultural chemicals, functional polymer materials and the like. With monohydroperfluoroalkane is reacted a base and then a carbonyl compound to produce an alcohol having a perfluoroalkyl group. For example, potassium hydroxide is made to interact with trifluoromethane, and a reaction with a carbonyl compound is induced to produce an alcohol having a trifluoromethyl group.

  提供了一种以单氢全氟烷烃为起始原料的全氟烷基化合物的简单生产工艺，全氟烷基化合物是有机电子材料、医药、农药、功能聚合物材料等的重要中间体。将单氢全氟烷烃与碱反应，然后与羰基化合物反应，生成具有全氟烷基的醇。例如，氢氧化钾与三氟甲烷发生作用，然后与羰基化合物发生反应，生成具有三氟甲基的醇。