Hexylmagnesiumiodid | 89583-95-9

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: Hexylmagnesiumiodid
• CAS: 89583-95-9
• 化学式: C₆H₁₃IMg
• 分子量: 236.379
• InChiKey: FEAXVNMZZBOUNO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.04
• 重原子数：
  8.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  Hexylmagnesiumiodid 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醚 、 苯 为溶剂， 反应 5.0h， 生成 1-(4-Hydroxy-3-methoxy-phenyl)-heptan-1-one
  参考文献：
  名称：

  Suri, O. P.; Bindra, R. S.; Satti, N. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 587 - 588

  摘要：

  DOI：
• 作为产物：
  描述：

  1-碘己烷 生成 Hexylmagnesiumiodid
  参考文献：
  名称：

  KATRITZKY, ALAN R.;RACHWAL, STANISLAW;OFFERMAN, RICK J.;NAJZAREK, ZBIGNIE+, CHEM. BER., 123,(1990) N, C. 1545-1551

  摘要：

  DOI：

文献信息

• Cyclopropenylcarbinol Derivatives as New Versatile Intermediates in Organic Synthesis: Application to the Formation of Enantiomerically Pure Alkylidenecyclopropane Derivatives
  作者：Samah Simaan、Ahmad Masarwa、Elinor Zohar、Amnon Stanger、Philippe Bertus、Ilan Marek

  DOI：10.1002/chem.200901074

  日期：2009.8.24

  The copper‐catalyzed carbomagnesiation (or hydrometalation) reaction of chiral cyclopropenylcarbinol derivatives, obtained by means of a kinetic resolution of secondary allylic alcohols, leads to an easy and straightforward preparation of enantiomerically pure alkylidenecyclopropane derivatives. The reaction mechanism is composed of a syn‐carbometalation followed by a syn‐elimination reaction. To gain

  通过仲烯丙醇的动力学拆分获得的手性环丙烯基甲醇衍生物的铜催化碳镁化（或加氢金属化）反应可以简单直接地制备对映体纯的亚烷基环丙烷衍生物。反应机理是顺式碳金属化，然后是顺式-消除反应。为了进一步了解碳金属化的反应机理，还实现了环丙基甲醇的非对映选择性形成，并且发现它对用于加成反应的有机金属物质的性质非常敏感。环丙醇也可以通过环丙烯基甲醇衍生物的非对映选择性还原来制备。最后，在温和条件下，将富含对映异构体的环丙烯基甲醇官能化为相应的乙酸酯或亚膦酸酯衍生物会导致各种对映异构体纯杂取代的亚烷基环丙烷。
• Benzylpiperazine derivatives. I. Syntheses and biological activities of 1-(2,3,4-trimethoxybenzyl)piperazine derivatives.
  作者：HIROSHI OHTAKA、MUTSUO MIYAKE、TOSHIRO KANAZAWA、KEIZO ITO、GORO TSUKAMOTO

  DOI：10.1248/cpb.35.2774

  日期：——

  A series of 1- (2, 3, 4-trimethoxybenzyl) piperazine (trimetazidine) derivatives were prepared and tested for cerebral vasodilating activity. Almost all the compounds possess stronger activity than trimetazidine and among them, the γ-amino tertiary alcohols 6e-j exhibit potent cerebral vasodilating activities which are superior to those of cinnarizine and papaverine. Moreover, these compounds show a selective vasodilating effect on vertebral arteries.

  合成了一系列1-（2, 3, 4-三甲氧基苄基）哌嗪（曲美他嗪）衍生物，并测试其脑血管扩张活性。几乎所有化合物的活性均强于曲美他嗪，其中γ-氨基三级醇6e-j表现出强大的脑血管扩张活性，优于辛那利嗪和罂粟碱。此外，这些化合物对椎动脉具有选择性的扩张作用。
• Benzylpiperazine derivatives. II. Syntheses and cerebral vasodilating activities of 1-((3-alkyl-3-hydroxy-3-phenyl)propyl)-4-benzylpiperazine derivatives.
  作者：HIROSHI OHTAKA、YOSHIAKI FUJIMOTO、KENJI YOSHIDA、TOSHIRO KANAZAWA、KEIZO ITO、GORO TSUKAMOTO

  DOI：10.1248/cpb.35.2782

  日期：——

  Analogs of 1-[ (3-alkyl-3-hydroxy-3-phenyl) propyl]-4- (2, 3, 4-trimethoxybenzyl) piperazine (1) were prepared and tested for cerebral vasodilating activity. It was found that the potency depends positively on the number of methoxyl groups on the benzyl moiety, and the homopiperazine analogs seem to be equipotent to the corresponding piperazines. From the standpoints of potency and ease of synthesis, 8k was selected for further study. Further analogs, which have various substituents in place of the benzyl moiety of 8k, were prepared and tested for cerebral vasodilating activity. These analogs were less potent than 8k. It was suggested that the benzyl moiety of 8k plays an important role in the high cerebral vasodilating activity.

  1-[ (3-烷基-3-羟基-3-苯基)丙基]-4- (2, 3, 4-三甲氧基苯基)哌嗪（1）的类似物被制备并测试了其脑血管扩张活性。研究发现，活性强度与苄基部分上的甲氧基团数量呈正相关，而同脉哌嗪类的类似物似乎与相应的哌嗪类同样具有活性。从活性和合成简便性来看，选定了8k进行进一步研究。随后制备了在8k的苄基部分替换为各种取代基的其他类似物，并测试了其脑血管扩张活性。这些类似物的活性均低于8k。研究者认为，8k的苄基部分在其高脑血管扩张活性中起着重要作用。
• Micellar extraction of the lanthanide ions from acidic media
  作者：Yu. G. Elistratova、A. R. Mustafina、D. A. Tatarinov、V. F. Mironov、A. I. Konovalov

  DOI：10.1007/s11172-009-0309-7

  日期：2009.11

  A procedure of micellar extraction of the lanthanide ions (La, Gd, and Lu) from nitric acid media based on the use of novel phosphine oxide derivatives is developed. In the micellar extraction, complexes of the lanthanide ions with the extractant in the ratio of 1 : 2 (metal : extractant) form. The dependence of the selectivity of extraction on the length of hydrophobic radicals attached to the P=O group was shown. The conditions of the selective micellar extraction in the series La > Gd > Lu with the use of an extractant containing octyl substituents at the P=O group were found.

  开发了一种基于使用新型氧化膦衍生物从硝酸介质中胶束萃取镧系离子（La、Gd 和 Lu）的方法。在胶束萃取中，镧系元素离子与萃取剂以 1:2（金属：萃取剂）的比例形成络合物。显示了萃取选择性对连接到 P=O 基团的疏水基团长度的依赖性。找到了使用 P=O 基团上含有辛基取代基的萃取剂对 La > Gd > Lu 系列中的选择性胶束萃取的条件。
• Process for preparing polyolefins
  申请人：NIPPON OIL COMPANY, LIMITED

  公开号：EP0507574A2

  公开（公告）日：1992-10-07

  A polyolefin having superior particle properties such as an extremely high bulk density, a large average particle diameter and a narrow particle size distribution, and having a narrow molecular weight distribution, is obtained in high yield, by polymerizing an olefin, using a catalyst comprising a solid catalyst component and an organometailic compound, the solid catalyst component being obtained by reacting a) a silicon oxide and/or an aluminum oxide, the reaction product of an organomagnesium compound and a compound of the general formula Me(OR)nXz - n and a titanium compound, in the presence of ROH, and further reacting the resulting reaction product with a compound of the general formula AlRqX3 - q.

  通过使用由固体催化剂组分和有机甲基化合物组成的催化剂聚合烯烃，可以高产率地获得一种具有优异颗粒特性（如极高的堆积密度、较大的平均颗粒直径和较窄的颗粒尺寸分布）且分子量分布较窄的聚烯烃、该固体催化剂组分是通过以下方式获得的：a) 氧化硅和/或氧化铝、有机镁化合物和通式 Me(OR)nXz - n 的化合物的反应产物以及钛化合物，在 ROH 存在下进行反应，并将所得反应产物与通式 AlRqX3 - q 的化合物进一步反应。