4-chloro-5-(3-(4-methylpiperazin-1-yI)phenoxy)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide | 1314806-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-chloro-5-(3-(4-methylpiperazin-1-yI)phenoxy)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide
• 英文别名: 4-chloro-5-(3-(4-methylpiperazin-1-yl)phenoxy)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide；US9617239, Brite-492794；4-chloro-5-[3-(4-methylpiperazin-1-yl)phenoxy]-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide
• CAS: 1314806-44-4
• 化学式: C₂₆H₂₆ClN₃O₃S₂
• 分子量: 528.096
• InChiKey: HUHCMXRNOWIRMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  98.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] PHÉNOXYTHIOPHÈNESULFONAMIDES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2011084503A1

  公开（公告）日：2011-07-14

  A compound, of formula (I): or a pharmaceutically acceptable salt thereof and a method of treating subject in need of potentiator of NGF-induced neurite growth using a compound of formula (I).

  一种化合物，其化学式为(I)，或其药学上可接受的盐，以及使用化合物(I)治疗需要神经生长因子诱导的神经元突起生长增强剂的受试者的方法。
• PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE
  申请人：NORTH CAROLINA CENTRAL UNIVERSITY

  公开号：US20160237058A1

  公开（公告）日：2016-08-18

  This invention relates generally to compounds that are glucuronidase inhibitors. The glucuronidase inhibitors include phenoxy thiophene sulfonamides, and other compounds such as pyridine sulfonyls, benzene sulfonyls, thiophene sulfonyls, thiazole sulfonyls, thiophene carbonyls, and thiazole carbonyls. These compounds include nialamide, isocarboxazid, phenelzine, amoxapine, loxapine and mefloquine. Also compositions including one or more of such compounds for use in inhibiting glucuronidase and methods of using one or more of such compounds for selective inhibition of bacterial β-glucoronidase. These compounds may be used as a co-drug in combination with the anticancer drug CPT-11. Also a method for screening compounds to determine their usefulness in reducing diarrhea associated with irinotecan chemotherapy.

  本发明涉及一般与葡萄糖醛酸酶抑制剂有关的化合物。这些葡萄糖醛酸酶抑制剂包括苯氧基噻吩磺酰胺和其他化合物，例如吡啶磺酰基、苯磺酰基、噻吩磺酰基、噻唑磺酰基、噻吩羰基和噻唑羰基。这些化合物包括尼氨胺、异卡泊嗪、苯妥英、阿莫西平、洛西平和美氟喹。此外，还包括含有一种或多种此类化合物的组合物，用于抑制葡萄糖醛酸酶，并使用一种或多种此类化合物进行细菌β-葡萄糖醛酸酶的选择性抑制的方法。这些化合物可作为联合抗癌药物CPT-11的辅助药物使用。还包括一种筛选化合物的方法，以确定它们在减少伊立替康化疗引起的腹泻方面的有用性。
• US9617239B2
  申请人：——

  公开号：US9617239B2

  公开（公告）日：2017-04-11