3,3-Dimethyl-1-(4-((6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidin-1-yl)butan-1-one | 1228105-99-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3,3-Dimethyl-1-(4-((6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidin-1-yl)butan-1-one
• 英文别名: 3,3-dimethyl-1-[4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidin-1-yl]butan-1-one
• CAS: 1228105-99-4
• 化学式: C₂₄H₄₀N₄O₄S
• 分子量: 480.672
• InChiKey: ZKIFREPYTWDDPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,3-二甲基丁酰氯 、 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3,3-Dimethyl-1-(4-((6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidin-1-yl)butan-1-one
  参考文献：
  名称：

  2,5-Disubstituted pyridines as potent GPR119 agonists

  摘要：

  A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.083

文献信息

• 2,5-Disubstituted pyridines as potent GPR119 agonists
  作者：Yulin Wu、Judith D. Kuntz、Andrew J. Carpenter、Jing Fang、Howard R. Sauls、Daniel J. Gomez、Carina Ammala、Yun Xu、Shane Hart、Sarva Tadepalli

  DOI：10.1016/j.bmcl.2010.02.083

  日期：2010.4

  A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor. (C) 2010 Elsevier Ltd. All rights reserved.