adinosine | 142031-35-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: adinosine
• 英文别名: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-ethyl-oxolane-3,4-diol；(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-ethyloxolane-3,4-diol
• CAS: 142031-35-4
• 化学式: C₁₁H₁₅N₅O₃
• 分子量: 265.272
• InChiKey: RLOSCLOIJYLPHI-IOSLPCCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  adinosine 在 吡啶 、 氯化亚砜 作用下， 以 乙腈 为溶剂， 以82%的产率得到5'-氯-5'-脱氧腺苷
  参考文献：
  名称：

  Structure-Guided Design of Fluorescent S-Adenosylmethionine Analogs for a High-Throughput Screen to Target SAM-I Riboswitch RNAs

  摘要：

  Many classes of S-adenosylmethionine (SAM)-binding RNAs and proteins are of interest as potential drug targets in diverse therapeutic areas, from infectious diseases to cancer. In the former case, the SAM-I riboswitch is an attractive target because this structured RNA element is found only in bacterial mRNAs and regulates multiple genes in several human pathogens. Here, we describe the synthesis of stable and fluorescent analogs of SAM in which the fluorophore is introduced through a functionalizable linker to the ribose. A Cy5-labeled SAM analog was shown to bind several SAM-I riboswitches via in-line probing and fluorescence polarization assays, including one from Staphylococcus aureus that controls the expression of SAM synthetase in this organism. A fluorescent ligand displacement assay was developed and validated for high-throughput screening of compounds to target the SAM-I riboswitch class.

  DOI：

  10.1016/j.chembiol.2014.01.004

文献信息

• PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF
  申请人：JAGTAP Prakash

  公开号：US20120264706A1

  公开（公告）日：2012-10-18

  The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

  本发明涉及嘌呤衍生物；包含有效量嘌呤衍生物的组合物；以及用于降低动物代谢率、保护动物心脏免受心肌停搏期间的心肌损伤；或用于治疗或预防心血管疾病、神经系统疾病、缺血性疾病、再灌注损伤、肥胖症、消耗性疾病或糖尿病的方法，包括向需要的动物中投与有效量的嘌呤衍生物。
• New genes related to a process for the production of fine chemicals
  申请人：Metanomics GmbH

  公开号：EP1953235A2

  公开（公告）日：2008-08-06

  The present invention relates to a process for the production of the fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.

  本发明涉及一种在微生物、植物细胞、植物、植物组织或其一个或多个部分中生产精细化学品的工艺。本发明还涉及核酸分子、多肽、核酸构建体、载体、反义分子、抗体、宿主细胞、植物组织、繁殖材料、收获材料、植物、微生物以及农业组合物及其用途。
• JPH05208993A
  申请人：——

  公开号：JPH05208993A

  公开（公告）日：1993-08-20
• BISUBSTRATE FLUORESCENT PROBE BINDING TO PROTEIN KINASES
  申请人：Uri Asko

  公开号：US20100233743A1

  公开（公告）日：2010-09-16

  This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the active concentration of protein kinases binding to the probe. Bisubstrate-analog character of the probe enables the simultaneous evaluation of inhibitors targeted to both ATP binding site and/or substrate protein/peptide binding domain of the kinase. High affinity of the probe (K d =1.0 nM towards cAMP-dependent protein kinase) affords the application of the enzymes at low concentration which leads to the substantial decrease of the consumption of the kinase. Due to the ability of the conjugates of oligo(D-arginine) with a ATP binding site targeted inhibitors of this invention to bind with high affinity to a wide spectrum of (basophilic) kinases, a single Fluorescent probe is applicable for assessment of inhibitory potency of compounds towards a great number of protein kinases.
• US7400979B2
  申请人：——

  公开号：US7400979B2

  公开（公告）日：2008-07-15