5-[N-[(1,3-Dioxolan-2-yl)methyl]-N-methylcarbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine | 250145-25-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[N-[(1,3-Dioxolan-2-yl)methyl]-N-methylcarbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine
• 英文别名: N-(1,3-dioxolan-2-ylmethyl)-N-methyl-6-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]pyridine-3-carboxamide
• CAS: 250145-25-6
• 化学式: C₂₄H₃₂N₆O₄
• 分子量: 468.556
• InChiKey: MWINAKFCTNGLNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• US6306860B1
  申请人：——

  公开号：US6306860B1

  公开（公告）日：2001-10-23
• [EN] NOVEL 2,5-PYRIDINEDICARBOXYLIC ACID DERIVATIVES<br/>[FR] NOUVEAUX DERIVES D'ACIDE 2,5-PYRIDINECARBOXYLIQUE
  申请人：DONG WHA PARM IND CO LTD

  公开号：WO1999058526A1

  公开（公告）日：1999-11-18

  The present invention relates to novel 2,5-pyridinedicarboxylic acid derivatives and more particularly, to novel 2,5-pyridinedicarboxylic acid derivatives of formula (1) and its pharmaceutically acceptable salts as anti retroviral agents, having inhibitory activities against the proliferation of retrovirus such as hepatitis B virus and human immunodeficiency virus, including its preparing method, wherein, R1, R2, R3 and n are the same as defined in the detailed description of the invention, respectively.