(2R)-N-(6-chloro-1,3-benzothiazol-2-yl)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide | 722497-56-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2R)-N-(6-chloro-1,3-benzothiazol-2-yl)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
• CAS: 722497-56-5
• 化学式: C₁₉H₁₇ClF₃N₅OS
• 分子量: 455.891
• InChiKey: NJCJFADEBLUOKP-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  89.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] BENZOAZOLYPIPERAZINE DERIVATIVES HAVING MGLUR1- AND MGLUR5-ANTAGONISTIC ACTIVITY<br/>[FR] DERIVES DE BENZOAZOLYLPIPERAZINE PRESENTANT UNE ACTIVITE ANTAGONISTE VIS-A-VIS DE MGLUR1 ET DE MGLUR5
  申请人：EURO CELTIQUE SA

  公开号：WO2004058754A1

  公开（公告）日：2004-07-15

  A compound of formula (I) wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson’s disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, retricted brain function, Huntington’s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of Benzoazolylpiperazine Compound are disclosed.

  公式（I）的化合物，其中Ar1，A，R3，x和m如本文所述，Ar2是苯并噻唑基，苯并噁唑基或苯并咪唑基或其药学上可接受的盐（“苯并咪唑基哌嗪化合物”），包含苯并咪唑基哌嗪化合物的组合物，并且揭示了治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾障碍，帕金森病，帕金森综合症，焦虑，癫痫，中风，癫痫发作，瘙痒症，精神病，认知障碍，记忆力缺失，受限的脑功能，亨廷顿舞蹈症，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动失调或抑郁症的方法，包括向需要治疗的动物中投与有效量的苯并咪唑基哌嗪化合物。
• BENZOAZOLYLPIPERAZINE DERIVATIVES HAVING VR1-ANTAGONIST ACTIVITY
  申请人：Euro-Celtique S.A.

  公开号：EP1583763B1

  公开（公告）日：2008-03-26
• THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
  申请人：Sun Qun

  公开号：US20100004254A1

  公开（公告）日：2010-01-07

  A compound of formula: wherein Ar 1 , A, R 3 , x, and m are as disclosed herein and Ar 2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.
• US7582635B2
  申请人：——

  公开号：US7582635B2

  公开（公告）日：2009-09-01
• US8008300B2
  申请人：——

  公开号：US8008300B2

  公开（公告）日：2011-08-30