1-(tert-butyldiphenylsiloxy)-2-pentanol | 139167-16-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1-(tert-butyldiphenylsiloxy)-2-pentanol
• 英文别名: 1-((tert-butyldiphenylsilyl)oxy)pentan-2-ol；1-[Tert-butyl(diphenyl)silyl]oxypentan-2-ol
• CAS: 139167-16-1
• 化学式: C₂₁H₃₀O₂Si
• 分子量: 342.554
• InChiKey: JMAYSWMHUJMVSE-UHFFFAOYSA-N

物化性质

• 沸点：
  407.6±37.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.72
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(tert-butyldiphenylsiloxy)-2-pentanol 在 重铬酸吡啶 、 4 A molecular sieve 、 四丁基氟化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 15.5h， 生成 2-cyclopropylidene-1-pentanol
  参考文献：
  名称：

  A concise and enantioselective approach to cyclobutanones by tandem asymmetric epoxidation and enantiospecific ring expansion of cyclopropylidene alcohols. An enantiocontrolled synthesis of (+)- and (-)-.alpha.-cuparenones

  摘要：

  A tandem Katsuki-Sharpless asymmetric epoxidation and enantiospecific ring expansion of 2-alkyl(or 2-aryl)-2-cyclopropylideneethanols (1a-i) afforded chiral 1-alkyl(or 1-aryl)-1-(hydroxymethyl)cyclobutanones (3a-i) in high yields and high enantiomeric excess. These compounds are potentially valuable synthons for the enantioselective creation of the quaternary carbons. Hence, this enabled us to accomplish a concise and enantioselective total synthesis of both (+)- and (-)-alpha-cuparenones (11).

  DOI：

  10.1021/jo00032a021
• 作为产物：
  描述：

  1,2-戊二醇 、 叔丁基二苯基氯硅烷 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 以99%的产率得到1-(tert-butyldiphenylsiloxy)-2-pentanol
  参考文献：
  名称：

  A concise and enantioselective approach to cyclobutanones by tandem asymmetric epoxidation and enantiospecific ring expansion of cyclopropylidene alcohols. An enantiocontrolled synthesis of (+)- and (-)-.alpha.-cuparenones

  摘要：

  A tandem Katsuki-Sharpless asymmetric epoxidation and enantiospecific ring expansion of 2-alkyl(or 2-aryl)-2-cyclopropylideneethanols (1a-i) afforded chiral 1-alkyl(or 1-aryl)-1-(hydroxymethyl)cyclobutanones (3a-i) in high yields and high enantiomeric excess. These compounds are potentially valuable synthons for the enantioselective creation of the quaternary carbons. Hence, this enabled us to accomplish a concise and enantioselective total synthesis of both (+)- and (-)-alpha-cuparenones (11).

  DOI：

  10.1021/jo00032a021

文献信息

• [EN] IMMUNOMODULATOR PURINE-DERIVED COMPOUNDS, CONJUGATES THEREOF, AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS DÉRIVÉS DE PURINE IMMUNOMODULATEURS, LEURS CONJUGUÉS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：[en]ZYMEWORKS BC INC.

  公开号：WO2024020684A1

  公开（公告）日：2024-02-01

  Disclosed are purine-derived compounds of general Formula (I), wherein X is O or NH; Y is CH or N; R1is an optionally substituted alkyl; n is 1 to 4; m is 0 to 4, R2is H, halogen, alkyl or alkoxy; each of R3and R1is H, OH, NR6R7, optionally substituted alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or R3, R4and N together may form a ring. Also disclosed are immunostimulatory antibody conjugates (ISACs) comprising such compounds, as well as methods for producing and using such compounds, e.g., for the treatment of diseases such as cancer.