1-benzyl-4-(3-methyl-4-p-tolyl-piperazin-1-yl)-phthalazine | 1057677-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-benzyl-4-(3-methyl-4-p-tolyl-piperazin-1-yl)-phthalazine
• 英文别名: 1-Benzyl-4-[3-methyl-4-(4-methylphenyl)piperazin-1-yl]phthalazine
• CAS: 1057677-13-0
• 化学式: C₂₇H₂₈N₄
• 分子量: 408.546
• InChiKey: HZNGEWZOSJOMNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Organic Compounds and Their Uses
  申请人：Dai Miao

  公开号：US20100069368A1

  公开（公告）日：2010-03-18

  The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders; specifically relating to compounds of formula I:

  本公开涉及与Hedgehog通路相关的病理诊断和治疗相关化合物，包括但不限于肿瘤形成、癌症、肿瘤新生和非恶性增生性疾病；具体涉及式I的化合物。
• ENHANCEMENT OF CHEMOTHERAPY EFFICIENCY BY SPHINGOSINE-1-PHOSPHATE
  申请人：AC BioScience

  公开号：EP3443986A1

  公开（公告）日：2019-02-20

  The present invention relates to neoadjuvant prior to chemotherapy. The present invention relates to sphingosine-1-phosphate pathway activator for use in the treatment of cancer as neoadjuvant prior to chemotherapy selected from sphingosine-1-phosphate, sphingosine-1-phosphate lyase inhibitor, sphingosine-1-phospahte receptor agonist and sphingosine kinase activator. The sphingosine-1-phosphate pathway activator enhances the chemotherapy efficiency through the normalization of intratumoral vascular network, promoting the effects of the sequential administration of an anticancer agent.

  本发明涉及化疗前的新辅助治疗。 本发明涉及选自鞘磷脂-1-磷酸、鞘磷脂-1-磷酸裂解酶抑制剂、鞘磷脂-1-磷酸受体激动剂和鞘磷脂激酶激活剂的用于治疗癌症的鞘磷脂-1-磷酸途径激活剂，作为化疗前的新辅助剂。 鞘氨醇-1-磷酸途径激活剂通过使瘤内血管网络正常化来提高化疗效率，促进抗癌剂连续给药的效果。
• ORGANIC COMPOUNDS AND THEIR USES
  申请人：Novartis AG

  公开号：EP2137162B1

  公开（公告）日：2018-08-01
• ENHANCEMENT OF CANCER TREATMENT EFFICIENCY VIA THE SPHINGOSINE-1-PHOSPHATE PATHWAY
  申请人：AC BioScience

  公开号：EP3668506A1

  公开（公告）日：2020-06-24
• US8536168B2
  申请人：——

  公开号：US8536168B2

  公开（公告）日：2013-09-17