3-((R)-1-methyl-pyrrolidin-3-yl)-5,5-diphenyl-imidazolidine-2,4-dione | 895148-85-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-((R)-1-methyl-pyrrolidin-3-yl)-5,5-diphenyl-imidazolidine-2,4-dione
• 英文别名: 3-[(3R)-1-methylpyrrolidin-3-yl]-5,5-diphenylimidazolidine-2,4-dione
• CAS: 895148-85-3
• 化学式: C₂₀H₂₁N₃O₂
• 分子量: 335.406
• InChiKey: IUFDLBVEBMISOU-QGZVFWFLSA-N

物化性质

• 密度：
  1.246±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-((R)-1-methyl-pyrrolidin-3-yl)-5,5-diphenyl-imidazolidine-2,4-dione 在 红铝 作用下， 以 四氢呋喃 、 甲苯 、 乙腈 为溶剂， 反应 6.0h， 生成 1-methyl-3-(R)-(2-oxo-4,4-diphenyl-imidazolidin-1-yl)-1-(2-phenoxy-ethyl)-pyrrolidinium iodide
  参考文献：
  名称：

  Discovery of Diaryl Imidazolidin-2-one Derivatives, a Novel Class of Muscarinic M3 Selective Antagonists (Part 2)

  摘要：

  Synthesis and biological activity of a novel class of quaternary ammonium salt muscarinic M3 receptor antagonists, showing high selectivity versus the M2 receptor, are described. Selected compounds exhibited potent anticholinergic properties, in isolated guinea-pig trachea, and good functional selectivity for trachea over atria. In vivo, the same compounds potently inhibited acetylcholine-induced bronchoconstriction after intratracheal administration in the guinea pig.

  DOI：

  10.1021/jm061160+
• 作为产物：
  描述：

  苯妥英 、 (S)-(+)-1-甲基-3-羟基吡咯烷 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 3-((R)-1-methyl-pyrrolidin-3-yl)-5,5-diphenyl-imidazolidine-2,4-dione
  参考文献：
  名称：

  Discovery of Diaryl Imidazolidin-2-one Derivatives, a Novel Class of Muscarinic M3 Selective Antagonists (Part 2)

  摘要：

  Synthesis and biological activity of a novel class of quaternary ammonium salt muscarinic M3 receptor antagonists, showing high selectivity versus the M2 receptor, are described. Selected compounds exhibited potent anticholinergic properties, in isolated guinea-pig trachea, and good functional selectivity for trachea over atria. In vivo, the same compounds potently inhibited acetylcholine-induced bronchoconstriction after intratracheal administration in the guinea pig.

  DOI：

  10.1021/jm061160+

文献信息

• Azole Derivatives With Antimuscarinic Activity
  申请人：Peretto Ilaria

  公开号：US20090005364A1

  公开（公告）日：2009-01-01

  The present invention relates to compounds of formula (I) wherein R1, R2, x, X, Y and B are as defined in the description for the treatment of muscarinic acetylcholine receptor mediated diseases, in particular M3 muscarinic receptor mediated diseases.

  本发明涉及式（I）的化合物，其中R1，R2，x，X，Y和B如所述的描述中所定义，用于治疗肌肉型乙酰胆碱受体介导的疾病，特别是M3肌肉型受体介导的疾病。