(R)-8-cyclopentyl-7-ethyl-2-[2-methoxy-5-(4-methyl-piperazin-1-yl)-phenylamino]-5-methyl-7,8-dihydro-5H-pteridin-6-one | 1159994-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-8-cyclopentyl-7-ethyl-2-[2-methoxy-5-(4-methyl-piperazin-1-yl)-phenylamino]-5-methyl-7,8-dihydro-5H-pteridin-6-one
• 英文别名: (7R)-8-cyclopentyl-7-ethyl-2-[2-methoxy-5-(4-methylpiperazin-1-yl)anilino]-5-methyl-7H-pteridin-6-one
• CAS: 1159994-48-5
• 化学式: C₂₆H₃₇N₇O₂
• 分子量: 479.625
• InChiKey: TZKOFEKVMCMJQE-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• SUBSTITUTED DIHYDROPTERIDIN-6-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
  申请人：Caruso Michele

  公开号：US20110053944A1

  公开（公告）日：2011-03-03

  Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本发明揭示了式（I）中所定义的Dihydropteridin-6-one衍生物及其药学上可接受的盐，以及它们的制备方法和包含它们的制药组合物；本发明的化合物在治疗与蛋白激酶活性失调相关的疾病，如癌症方面可能有用。
• US8598172B2
  申请人：——

  公开号：US8598172B2

  公开（公告）日：2013-12-03
• [EN] SUBSTITUTED DIHYDROPTERIDIN-6-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE DIHYDROPTÉRIDIN-6-ONE SUBSTITUÉS, PROCÉDÉ DE PRÉPARATION DESDITS DÉRIVÉS ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE KINASE
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2009071480A2

  公开（公告）日：2009-06-11

  Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.