1-(2,4-dimethylphenyl)-4-(5-isopropyl-2-methoxybenzyl)piperazine | 1206846-56-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2,4-dimethylphenyl)-4-(5-isopropyl-2-methoxybenzyl)piperazine
• 英文别名: 1-(2,4-Dimethylphenyl)-4-[(2-methoxy-5-propan-2-ylphenyl)methyl]piperazine
• CAS: 1206846-56-1
• 化学式: C₂₃H₃₂N₂O
• 分子量: 352.52
• InChiKey: IDQAXLOWICUZSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 5HT7 receptor ligands and compositions comprising the same
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2149373A1

  公开（公告）日：2010-02-03

  The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.

  本发明涉及具有药理活性的化合物，特别是作为5-HT7受体激动剂，通过使用药效团和描述符的配置文件筛选识别，以及包含它们的药物组合物。这些化合物在治疗中特别有用，特别是用于治疗和/或预防涉及5-HT7的疾病，如中枢神经系统紊乱。
• 5HT7 RECEPTOR LIGANDS AND COMPOSITIONS COMPRISING THE SAME
  申请人：Pascual-Ramon Rosalia

  公开号：US20110183991A1

  公开（公告）日：2011-07-28

  The present invention relates to compounds having pharmacological activity towards the 5-HT 7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT 7 is involved, such as CNS disorders.