1,3-Dimethyl-3-phenyl-piperidin | 35172-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,3-Dimethyl-3-phenyl-piperidin
• 英文别名: 1,3-Dimethyl-3-phenylpiperidine
• CAS: 35172-28-2
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: XTJQLZMFXVBHFU-UHFFFAOYSA-N

物化性质

• 沸点：
  262.4±19.0 °C(Predicted)
• 密度：
  0.945±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,5-dimethyl-1,2,3,6-tetrahydro-pyridine 、 苯 在 三氟甲磺酸 作用下， 反应 4.0h， 以87%的产率得到1,3-Dimethyl-3-phenyl-piperidin
  参考文献：
  名称：

  Superacid-catalyzed preparation of aryl-substituted piperidines via dicationic electrophiles

  摘要：

  The electrophilic chemistry of 1,2,3,6-tetrahydropyridines has been studied in the Bronsted superacid, CF3SO3H (triflic acid). The 1,2,3,6-tetrahydropyridines react with arenes to give aryl-substituted piperidines. It is proposed that the reactions occur through dicationic electrophilic intermediates. Depending upon substituents, either 1,4-dications or 1,3-dications are formed. The dicationic intermediates react with moderately deactivated arenes, such as o-dichlorobenzene. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01130-3

文献信息

• 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
  申请人：Janssen Pharmaceuticals, Inc.

  公开号：EP2661435B1

  公开（公告）日：2015-08-19
• Superacid-catalyzed preparation of aryl-substituted piperidines via dicationic electrophiles
  作者：Douglas A Klumpp、Philip S Beauchamp、Gregorio V Sanchez、Sharon Aguirre、Sarah de Leon

  DOI：10.1016/s0040-4039(01)01130-3

  日期：2001.8

  The electrophilic chemistry of 1,2,3,6-tetrahydropyridines has been studied in the Bronsted superacid, CF3SO3H (triflic acid). The 1,2,3,6-tetrahydropyridines react with arenes to give aryl-substituted piperidines. It is proposed that the reactions occur through dicationic electrophilic intermediates. Depending upon substituents, either 1,4-dications or 1,3-dications are formed. The dicationic intermediates react with moderately deactivated arenes, such as o-dichlorobenzene. (C) 2001 Elsevier Science Ltd. All rights reserved.