8-Aminoguanosine triphosphate | 101212-50-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 8-Aminoguanosine triphosphate
• 英文别名: [[(2R,3S,4R,5R)-5-(2,8-diamino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 101212-50-4
• 化学式: C₁₀H₁₇N₆O₁₄P₃
• 分子量: 538.2
• InChiKey: IJSGACPSCFCCED-UMMCILCDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  321
• 氢给体数：
  9
• 氢受体数：
  16

文献信息

• Pterin-dependent biocatalysts and uses thereof
  申请人：Georgia Tech Research Corporation

  公开号：US11085060B2

  公开（公告）日：2021-08-10

  Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway biologically coupled to the pterin source. Tetrahydrobiopterin (referred to herein as BH4 or BH 4) can be the pterin source. The BH4 can be synthesized by a tetrahydrobiopterin synthesis pathway. The tetrahydrobiopterin synthesis pathway can include a GTP cyclohydrase; a pyruvoyl tetrahydropterin synthase; a sepiapterin reductase, and/or any combination thereof. The biocatalyst can further contain a pterin-dependent enzymatic pathway. The pterin-dependent enzymatic pathway can be amino acid mono-oxygenase, phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, nitric oxide synthase, alkylglycerol monooxygenase, and/or any combination thereof.

  本文提供了用于蝶呤依赖性酶和途径的生物催化剂及其系统，以及制造和使用这些催化剂的方法。在某些实施方案中，本文提供了具有蝶呤源和与蝶呤源生物耦合的蝶呤依赖性酶途径的生物催化剂。四氢生物蝶呤（在此称为 BH4 或 BH 4）可以是蝶呤源。 可以通过四氢生物蝶呤合成途径合成。四氢生物蝶呤合成途径可包括 GTP 环水解酶、丙酮酰四氢蝶呤合成酶、sepiapterin 还原酶和/或它们的任意组合。生物催化剂可进一步包含蝶呤依赖性酶途径。蝶呤依赖性酶途径可以是氨基酸单加氧酶、苯丙氨酸羟化酶、色氨酸羟化酶、酪氨酸羟化酶、一氧化氮合酶、烷基甘油单加氧酶和/或它们的任意组合。
• PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF
  申请人：Georgia Tech Research Corporation

  公开号：US20170362617A1

  公开（公告）日：2017-12-21

  Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway biologically coupled to the pterin source. Tetrahydrobiopterin (referred to herein as BH4 or BH 4) can be the pterin source. The BH4 can be synthesized by a tetrahydrobiopterin synthesis pathway. The tetrahydrobiopterin synthesis pathway can include a GTP cyclohydrase; a pyruvoyl tetrahydropterin synthase; a sepiapterin reductase, and/or any combination thereof. The biocatalyst can further contain a pterin-dependent enzymatic pathway. The pterin-dependent enzymatic pathway can be amino acid mono-oxygenase, phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, nitric oxide synthase, alkylglycerol monooxygenase, and/or any combination thereof.
• [EN] PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF<br/>[FR] BIOCATALYSEURS PTÉRINE-DÉPENDANTS ET UTILISATIONS DE CEUX-CI
  申请人：GEORGIA TECH RES INST

  公开号：WO2016109769A1

  公开（公告）日：2016-07-07

  Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway biologically coupled to the pterin source. Tetrahydrobiopterin (referred to herein as BH4 or BH 4) can be the pterin source. The BH4 can be synthesized by a tetrahydrobiopterin synthesis pathway. The tetrahydrobiopterin synthesis pathway can include a GTP cyclohydrase; a pyruvoyl tetrahydropterin synthase; a sepiapterin reductase, and/or any combination thereof. The biocatalyst can further contain a pterin-dependent enzymatic pathway. The pterin-dependent enzymatic pathway can be amino acid mono-oxygenase, phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, nitric oxide synthase, alkylglycerol monooxygenase, and/or any combination thereof.