4-甲基-4,5-二氢-噻唑-2-基胺 | 10416-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 中文名称: 4-甲基-4,5-二氢-噻唑-2-基胺
• 英文名称: 2-Amino-4-methyl-Δ²-thiazolin
• 英文别名: 4-methyl-4,5-dihydro-thiazol-2-ylamine；2-amino-4-methylthiazoline；2-amino-4-methyl-2-thiazoline；4-methyl-4,5-dihydro-1,3-thiazol-2-amine
• CAS: 10416-81-6；58895-92-4
• 化学式: C₄H₈N₂S
• mdl: MFCD19236761
• 分子量: 116.187
• InChiKey: SILRNKZBMNSABG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-甲基-4,5-二氢-噻唑-2-基胺 、 2-氯-5-氯甲基吡啶 生成 3-(6-chloro-3-pyridyl)methyl-2-imino-4-methylthiazolidine hydrochloride
  参考文献：
  名称：

  EP1176141

  摘要：

  公开号：

文献信息

• 2,3,6,7-Tetrahydrothiazolo[3,2-a]pyrimidine derivatives having
  申请人：Rhone-Poulenc Industries

  公开号：US04419356A1

  公开（公告）日：1983-12-06

  Thiazolo[3,2-a]pyrimidine derivative of the formula: ##STR1## wherein R represents phenyl, alkyl of 1 through 4 carbon atoms, alkyl of 1 through 4 carbon atoms substituted by 1 through 3 halogen atom, alkenyl of 2 through 4 carbon atoms, or cycloalkyl of 3 through 6 carbon atoms and R.sub.1 represents hydrogen, or R and R.sub.1 each represent phenyl or unsubstituted alkyl of 1 through 4 carbon atoms, or R and R.sub.1 together represent an alkylene radical of 4 or 5 carbon atoms, and R.sub.2 and R.sub.3 each represent hydrogen or unsubstituted alkyl of 1 through 4 carbon atoms, or R and R.sub.1 each represent hydrogen, and one of R.sub.2 and R.sub.3 represents hydrogen and the other represents unsubstituted alkyl of 1 through 4 carbon atoms, or R.sub.2 and R.sub.3 both represent unsubstituted alkyl of 1 through 4 carbon atoms, are new compounds possessing pharmacological properties. They are especially useful in the treatment of rheumatic disease or allergic states, or as analgesics. Processes for the preparation of the compounds are described.

  该化合物为Thiazolo [3,2-a]吡咯嘧啶衍生物，其化学式为：##STR1## 其中R代表苯基，1至4个碳原子的烷基，1至4个碳原子的烷基被1至3个卤素原子取代，2至4个碳原子的烯基或3至6个碳原子的环烷基，R.sub.1代表氢，或R和R.sub.1各自代表苯基或未取代的1至4个碳原子的烷基，或R和R.sub.1一起代表4或5个碳原子的烷基，R.sub.2和R.sub.3各自代表氢或未取代的1至4个碳原子的烷基，或R和R.sub.1各自代表氢，而R.sub.2和R.sub.3中的一个代表氢，另一个代表未取代的1至4个碳原子的烷基，或R.sub.2和R.sub.3都代表未取代的1至4个碳原子的烷基，是具有药理学特性的新化合物。它们在治疗风湿病或过敏状态或作为镇痛剂方面特别有用。描述了制备该化合物的过程。
• Di-substituted imineheterocyclic compounds
  申请人：——

  公开号：US20030078259A1

  公开（公告）日：2003-04-24

  There is provided di-substituted iminoheterocyclic compounds of the following formula (I): 1 in which, A is optionally substituted alkyl group, optionally substituted aryl group or optionally substituted heterocyclic group; X is oxygen atom, sulfur atom, carbon atom or nitrogen atom; the group —X—Y— represents optionally substituted alkylene or cyclic alkenylene bond; and B 1 and B 2 are, hydrogen atom, optionally substituted alkyl group, optionally substituted aryl group or optionally substituted heterocyclic group, independent from each other, or a pharmaceutically acceptable salt thereof. These compounds have good affinity for &agr;4&bgr;2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.

  提供以下式子（I）的二取代亚胺杂环化合物：1其中，A是可选取代的烷基，可选取代的芳基或可选取代的杂环基；X是氧原子，硫原子，碳原子或氮原子；组- X-Y-表示可选取代的烷基或环烯基键；B1和B2独立于彼此，是氢原子，可选取代的烷基，可选取代的芳基或可选取代的杂环基，或其药学上可接受的盐。这些化合物对α4β2型烟碱乙酰胆碱受体具有良好的亲和力，并激活该受体，从而对脑功能障碍发挥预防或治疗作用。
• Bratulescu, George, Asian Journal of Chemistry, 2012, vol. 24, # 1, p. 350 - 352
  作者：Bratulescu, George

  DOI：——

  日期：——
• EP1176141
  申请人：——

  公开号：——

  公开（公告）日：——