檀香酸 | 469-70-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 檀香酸
• 英文名称: (+/-)-1,2c-dimethyl-cyclopentane-1r,3c-dicarboxylic acid
• 英文别名: (+/-)-1,2c-Dimethyl-cyclopentan-1r,3c-dicarbonsaeure；(+/-)-cis-Allosantensaeure
• CAS: 469-70-5；469-71-6；30636-86-3
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: TYONAVFDKTWOJC-ATVXKPNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  13.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  檀香酸 在 溴 、 五溴化磷 作用下， 生成 2,3-dimethyl-cyclopent-1-ene-1,3-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Komppa; Rohrmann, Annales Academiae Scientiarum Fennicae, Series A, 1935, vol. 44, p. 3,25

  摘要：

  DOI：
• 作为产物：
  描述：

  1,syn-7-dimethylbicyclo<2.2.1>heptan-2-exo-ol 在 potassium permanganate 作用下， 生成 檀香酸
  参考文献：
  名称：

  Beckmann; Duerkop, Justus Liebigs Annalen der Chemie, 1955, vol. 594, p. 205,211

  摘要：

  DOI：

文献信息

• Komppa; Nyman, Annales Academiae Scientiarum Fennicae, Series A, 1935, vol. 45, # 1, p. 6
  作者：Komppa、Nyman

  DOI：——

  日期：——
• Nishimitsu, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 343,345
  作者：Nishimitsu

  DOI：——

  日期：——
• Chakravarti, Journal of the Indian Chemical Society, 1943, vol. 20, p. 247
  作者：Chakravarti

  DOI：——

  日期：——
• L’addition d’hydromorphone à l’injection épidurale de fentanyl n’affecte pas l’analgésie au début du travail
  作者：Robert K. Parker、Neil Roy Connelly、Tanya Lucas、Uzma Faheem、Asad Syed Rizvi、Mervat El-Mansouri、Nikhil Thakkar、Ramchander Kamasumadram、Kelly Dixon、Steven M. Dunn、Charles Gibson

  DOI：10.1007/bf03017388

  日期：2002.6

  Purpose: Epidural fentanyl after a lidocaine and epinephrine test dose, provides adequate analgesia and allows for ambulation during early labour. The current study was designed to determine the influence of hydromorphone added to an epidural fentanyl bolus (e.g., whether there is an increase in duration of analgesia).Methods: Forty-four labouring primigravid women, at less than 5 cm cervical dilation, who requested epidural analgesia were enrolled in this randomized, double-blind study. After a 3 mL test dose of lidocaine with epinephrine, patients received fentanyl 100 mug (in 10 mL volume). They randomly received the fentanyl with either saline or hydromorphone (300 mug). After administration of the initial analgesic, pain scores and side effects were recorded for each patient at. ten, 20, and 30 min, and every 30 min thereafter, by an observer blinded to the technique used.Results: The patients were taller in the hydromorphone group (P < 0.04). There were no other demographic differences between the two groups. The mean duration prior to re-dose was not significantly different in the group that received hydromorphone (135 +/- 52 min) compared to the control group (145 +/- 46 min). Side effects were similar between the two groups. No patient in either group experienced any detectable motor block.Conclusion: In early labouring patients, the addition of hydromorphone (300 mug) to epidural fentanyl (100 mug after a lidocaine and epinephrine test dose) neither prolongs the duration of analgesia nor affects the ability to ambulate, and cannot be recommended according to the current study.
• Enkvist, Suomen Kemistiseuran Tiedonantoja, <hi>1932</hi>, vol. 41, p. 74,81
  作者：Enkvist

  DOI：——

  日期：——