10-(4-ethylpiperazin-1-yl)-6,11-dihydro-5h-indeno[1,2-h][1,6]naphthyridin-5-one | 1233479-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 10-(4-ethylpiperazin-1-yl)-6,11-dihydro-5h-indeno[1,2-h][1,6]naphthyridin-5-one
• 英文别名: 10-(4-Ethylpiperazin-1-yl)-6,11-dihydroindeno[1,2-h][1,6]naphthyridin-5-one
• CAS: 1233479-36-1
• 化学式: C₂₁H₂₂N₄O
• 分子量: 346.432
• InChiKey: QPMSDCIGUGVEOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED TETRACYCLIC 1H-INDENO [1,2-B]PYRIDINE-2(5H)-ONE ANALOGS THEREOF AND USES THEREOF
  申请人：JAGTAP Prakash

  公开号：US20100261706A1

  公开（公告）日：2010-10-14

  Provided herein are tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analogs and derivatives, compositions comprising an effective amount of a tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analog and/or derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, a reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, an ocular or opthalmologic disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, contrast induced nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of a tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analog or derivative.

  本文提供四环1H-吲哚[1,2-b]吡啶-2(5H)-酮类似物和衍生物，包括含有效量四环1H-吲哚[1,2-b]吡啶-2(5H)-酮类似物和/或衍生物的组合物以及治疗或预防炎症性疾病、再灌注损伤、糖尿病、糖尿病并发症、器官移植引起的再氧化损伤、缺血症、神经退行性疾病、肾功能衰竭、血管疾病、心血管疾病、眼部或眼科疾病、癌症、早产并发症、心肌病、视网膜病、肾病、造影剂诱导性肾病、神经病和勃起功能障碍或尿失禁的方法，包括向需要的受体施用有效量的四环1H-吲哚[1,2-b]吡啶-2(5H)-酮类似物或衍生物。
• [EN] SUBSTITUTED TETRACYCLIC 1H-INDENO (1,2-B) PYRIDINE-2 (5H)-ONE ANALOGS THEREOF AND USES THEREOF<br/>[FR] ANALOGUES TÉTRACYCLIQUES SUBSTITUÉS DE 1H-INDÉNO(1,2-B)PYRIDINE-2(5H)-ONE ET LEURS UTILISATIONS
  申请人：INOTEK PHARMACEUTICALS CORP

  公开号：WO2010077663A2

  公开（公告）日：2010-07-08

  Provided herein are tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analogs and derivatives, compositions comprising an effective amount of a tetracyclic 1H- indeno[1,2-b]pyridine-2(5H)-one analog and/or derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, a reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, an ocular or ophthalmologic disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, contrast induced nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of a tetracyclic 1H- indeno[1,2-b]pyridine-2(5H)-one analog or derivative.