8-(2-furyl)-2-{[4-(4-isopropylpiperazin-1-yl)-3-methylphenyl]amino}-6-(2-methylphenyl)pyrimido[4,5-d]pyridazin-5(6H)-one | 1419772-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8-(2-furyl)-2-{[4-(4-isopropylpiperazin-1-yl)-3-methylphenyl]amino}-6-(2-methylphenyl)pyrimido[4,5-d]pyridazin-5(6H)-one
• 英文别名: 8-(Furan-2-yl)-6-(2-methylphenyl)-2-[3-methyl-4-(4-propan-2-ylpiperazin-1-yl)anilino]pyrimido[4,5-d]pyridazin-5-one
• CAS: 1419772-34-1
• 化学式: C₃₁H₃₃N₇O₂
• 分子量: 535.649
• InChiKey: UTSCWWZANKIZJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] PYRIDAZINO [4, 5 -D] PYRIMIDIN- (6H) -ONE INHIBITORS OF WEE - 1 KINASE<br/>[FR] INHIBITEURS DE KINASE WEE-1 DE TYPE PYRIDAZINO[4,5-D]PYRIMIDIN-(6H)ONE
  申请人：ABBVIE INC

  公开号：WO2013013031A1

  公开（公告）日：2013-01-24

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, Formula (I) wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

  本发明涉及公式(I)化合物或其药学上可接受的盐，公式(I)中B、R1、R2、R4和m的定义见说明书。本发明还涉及含有上述化合物的组合物，其对抑制wee-1等激酶有用，并且用于治疗癌症等疾病的方法。
• PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES
  申请人：Zhu Gui-Dong

  公开号：US20130023523A1

  公开（公告）日：2013-01-24

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R 1 , R 2 , R 4 , and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

  本发明涉及式(I)的化合物或药物可接受的盐，其中B、R1、R2、R4和m在说明书中有定义。本发明还涉及含有所述化合物的组合物，该组合物对于抑制wee-1等激酶以及治疗癌症等疾病的方法是有用的。
• HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Sunovion Pharmaceuticals Inc.

  公开号：US20140288062A1

  公开（公告）日：2014-09-25

  Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

  本文提供了杂环芳基化合物、其合成方法、包含该化合物的制药组合物以及使用该化合物的方法。在一种实施方式中，本文提供的化合物可用于治疗、预防和/或管理各种疾病，例如中枢神经系统疾病和代谢性疾病，包括但不限于神经系统疾病、精神病、精神分裂症、肥胖症和糖尿病。
• US8796289B2
  申请人：——

  公开号：US8796289B2

  公开（公告）日：2014-08-05
• US9051327B2
  申请人：——

  公开号：US9051327B2

  公开（公告）日：2015-06-09