tert-butyl 4-((3S,5R)-5-(4-fluorophenyl)-3-(hydroxycarbamoyl)-5-methoxypentyl)piperazine-1-carboxylate | 1100156-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl 4-((3S,5R)-5-(4-fluorophenyl)-3-(hydroxycarbamoyl)-5-methoxypentyl)piperazine-1-carboxylate
• 英文别名: tert-butyl 4-[(3S,5R)-5-(4-fluorophenyl)-3-(hydroxycarbamoyl)-5-methoxypentyl]piperazine-1-carboxylate
• CAS: 1100156-78-2
• 化学式: C₂₂H₃₄FN₃O₅
• 分子量: 439.527
• InChiKey: BXZZNLOHMVZLBY-PKOBYXMFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  91.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Hydroxamic acid derivatives of 4-phenyl 4-hydroxy, 4-phenyl 4-alkoxy and 4-phenyl 4-arylalkoxy butyric acid useful as therapeutic agents for treating anthrax poisoning
  申请人：Johnson Alan T.

  公开号：US20100286125A1

  公开（公告）日：2010-11-11

  Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 4-phenyl-4-hydroxy-butyric acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

  具有以下式的化合物是4-苯基-4-羟基丁酸的羟肟酸衍生物，能够抑制炭疽细菌感染的致命效应，并且在炭疽中毒的治疗中有用。
• US8119692B2
  申请人：——

  公开号：US8119692B2

  公开（公告）日：2012-02-21
• [EN] HYDROXAMIC ACID DERIVATIVES OF 4-PHENYL 4-HYDROXY, 4-PHENYL 4-ALKOXY AND 4-PHENYL 4-ARYLALKOXY BUTYRIC ACID USEFUL AS THERAPEUTIC AGENTS FOR TREATING ANTHRAX POISONING<br/>[FR] DÉRIVÉS D'ACIDE HYDROXAMIQUE D'ACIDE 4-PHENYL 4-HYDROXY, 4-PHENYL 4-ALKOXY AND 4-PHENYL 4-ARYLALKOXY BUTYRIQUE UTILISÉS COMME AGENTS THÉRAPEUTIQUES POUR TRAITER UN EMPOISONNEMENT PAR LE BACILLE DU CHARBON
  申请人：PANTHERA BIOPHARMA LLC

  公开号：WO2009008920A2

  公开（公告）日：2009-01-15

  Compounds having the formula : (I) wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 4-phenyl-4-hydroxy-butyric acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.