4-(4-allylpiperazin-1-yl)-2-chloroquinazoline | 134961-17-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-allylpiperazin-1-yl)-2-chloroquinazoline
• 英文别名: 2-chloro-4-(4-prop-2-enylpiperazin-1-yl)quinazoline
• CAS: 134961-17-4
• 化学式: C₁₅H₁₇ClN₄
• 分子量: 288.78
• InChiKey: OISYBGAYUWMIJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二氯喹唑啉 、 1-烯丙基哌嗪 在 sodium hydroxide 作用下， 以 甲苯 为溶剂， 反应 0.5h， 以46%的产率得到4-(4-allylpiperazin-1-yl)-2-chloroquinazoline
  参考文献：
  名称：

  Reaction of quinazoline-2,4(1H,3H)-dione with N-substituted cyclic amines in combination with phosphoryl trichloride

  摘要：

  The reaction of quinazoline-2,4(1H,3H)-dione with N-allyl, N-benzyl and N-methyl cyclic amines in combination with phosphoryl trichloride in the presence of tripropylamine in 1,4-dioxane afforded 4-chloro-2-(cycloalkylamino)quinazolines. In the case of N-substituted pyrrolidines, 4-chloro-2-(N-substituted 4-chlorobutylamino) quinazolines were also obtained.

  DOI：

  10.1039/p19910001279

文献信息

• Reaction of quinazoline-2,4(1H,3H)-dione with N-substituted cyclic amines in combination with phosphoryl trichloride
  作者：Kenji Yoshida、Takashi Tanaka、Hiroshi Ohtaka

  DOI：10.1039/p19910001279

  日期：——

  The reaction of quinazoline-2,4(1H,3H)-dione with N-allyl, N-benzyl and N-methyl cyclic amines in combination with phosphoryl trichloride in the presence of tripropylamine in 1,4-dioxane afforded 4-chloro-2-(cycloalkylamino)quinazolines. In the case of N-substituted pyrrolidines, 4-chloro-2-(N-substituted 4-chlorobutylamino) quinazolines were also obtained.

表征谱图