1-methoxycarbonyl-2-(2-oxocyclopentyl)piperidine | 1271934-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-methoxycarbonyl-2-(2-oxocyclopentyl)piperidine
• 英文别名: Methyl 2-(2-oxocyclopentyl)piperidine-1-carboxylate；methyl 2-(2-oxocyclopentyl)piperidine-1-carboxylate
• CAS: 1271934-08-7
• 化学式: C₁₂H₁₉NO₃
• 分子量: 225.288
• InChiKey: SSIFSFKWKJYTAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(三甲基硅氧基)环戊烯 、 2-methoxy-piperidine-1-carboxylic acid methyl ester 在 四氯化钛 、 苯基三氯硅烷 作用下， 以 二氯甲烷 为溶剂， 以67%的产率得到1-methoxycarbonyl-2-(2-oxocyclopentyl)piperidine
  参考文献：
  名称：

  Mannich-Type Reaction of N,O-Acetals with Ketones Mediated by a Combination of TiCl4 and PhSiCl3

  摘要：

  A combination of TiCl4 and PhSiCl3 efficiently conducts the Mannich-type reaction of N,O-acetals with ketones to afford a-substituted cyclic amine derivatives in good yields. This method was applicable to preparation of azabicyclo compounds by the intramolecular Mannich-type reaction.

  DOI：

  10.3987/com-09-s(e)2

文献信息

• Mannich-Type Reaction of N,O-Acetals with Ketones Mediated by a Combination of TiCl4 and PhSiCl3
  作者：Osamu Onomura、Takashi Ikeda、Masami Kuriyama、Yoshihiro Matsumura、Satoshi Kamogawa

  DOI：10.3987/com-09-s(e)2

  日期：——

  A combination of TiCl4 and PhSiCl3 efficiently conducts the Mannich-type reaction of N,O-acetals with ketones to afford a-substituted cyclic amine derivatives in good yields. This method was applicable to preparation of azabicyclo compounds by the intramolecular Mannich-type reaction.