5-(5-((2R)-2-[5-(3-chlorophenyl)isoxazol-3-yl]pyrrolidin-1-yl)-4-methyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine | 1146111-51-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-(5-((2R)-2-[5-(3-chlorophenyl)isoxazol-3-yl]pyrrolidin-1-yl)-4-methyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine
• 英文别名: 5-[5-[(2R)-2-[5-(3-chlorophenyl)-1,2-oxazol-3-yl]pyrrolidin-1-yl]-4-methyl-1,2,4-triazol-3-yl]pyridin-2-amine
• CAS: 1146111-51-4
• 化学式: C₂₁H₂₀ClN₇O
• 分子量: 421.889
• InChiKey: PYSWUXQGNAXKHL-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  98.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• AMINOPYRIDINE DERIVATIVES AS MODULATORS OF MGLUR5
  申请人：GRANBERG Kenneth

  公开号：US20090111823A1

  公开（公告）日：2009-04-30

  The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

  本发明涉及新型化合物，其制备方法，它们在治疗中的应用以及包含这些新型化合物的药物组合物。
• [EN] AMINOPYRIDINE DERIVATIVES AS MODULATORS OF MGLUR5<br/>[FR] DÉRIVÉS D'AMINOPYRIDINE UTILISÉS EN TANT QUE MODULATEURS DE MGLUR5
  申请人：ASTRAZENECA AB

  公开号：WO2009054792A1

  公开（公告）日：2009-04-30

  The present invention is directed to novel compounds (I) as modulators of metabotropic glutamate receptors (mG1uRs) 1. A compound of formula (I) wherein R1 is methyl. halogen or cyano; R2 h hydrogen or fluoro: R3 isC1-C3 tlfeyi or cyclopropyl; X is (Formula) to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds