1,3-dimethyl-6-{4-[4-(4-nitrophenoxy)butyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione hydrochloride | 130636-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,3-dimethyl-6-{4-[4-(4-nitrophenoxy)butyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione hydrochloride
• 英文别名: 1,3-Dimethyl-6-[4-[4-(4-nitrophenoxy)butyl]piperazin-1-yl]pyrimidine-2,4-dione;hydrochloride
• CAS: 130636-98-5
• 化学式: C₂₀H₂₇N₅O₅*ClH
• 分子量: 453.926
• InChiKey: CEJBGRLMYKAUKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Long-acting drug formulation containing pyrimidinedione derivatives
  申请人：MITSUI TOATSU CHEMICALS, INC.

  公开号：EP0722732A1

  公开（公告）日：1996-07-24

  Treatment of arrhythmia requires administration of an antiarrhythmic drug over a long period of time. A long-acting drug formulation for oral administration, which is safe and effective for the treatment of arrhythmia, has been provided. This long-acting antiarrhythmic formulation comprises at least one unit I and at least one unit II. The unit I comprises as an effective ingredient a pyrimidinedione derivative having antiarrhythmic action and represented by the following formula (1): and promptly releases the effective ingredient in the stomach. On the other hand, the unit II is composed of a core, which comprises the same effective ingredient, and an enteric coat surrounding the core. The unit II promptly releases the effective ingredient in the small intestine.

  治疗心律失常需要长期服用抗心律失常药物。现已提供一种用于口服的长效药物制剂，它对治疗心律失常安全有效。这种长效抗心律失常制剂包括至少一个单元 I 和至少一个单元 II。单元 I 作为有效成分包括一种具有抗心律失常作用的嘧啶二酮衍生物，由下式(1)表示： 并在胃中迅速释放有效成分。另一方面，单元 II 由包含相同有效成分的核心和围绕核心的肠衣组成。单元 II 可在小肠中迅速释放有效成分。
• Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0369627B1

  公开（公告）日：1994-12-21
• US5008267A
  申请人：——

  公开号：US5008267A

  公开（公告）日：1991-04-16