[4-[(3-Methoxyoxan-4-yl)amino]piperidin-1-yl]-[6-[4-[3-methoxy-5-(trifluoromethyl)phenyl]piperazin-1-yl]-5-methylpyrimidin-4-yl]methanone | 1349196-86-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [4-[(3-Methoxyoxan-4-yl)amino]piperidin-1-yl]-[6-[4-[3-methoxy-5-(trifluoromethyl)phenyl]piperazin-1-yl]-5-methylpyrimidin-4-yl]methanone
• CAS: 1349196-86-6
• 化学式: C₂₉H₃₉F₃N₆O₄
• 分子量: 592.662
• InChiKey: ZIYHEVOJPZWGOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• NOVEL CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS
  申请人：Ebel Heiner

  公开号：US20130123241A1

  公开（公告）日：2013-05-16

  The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) wherein HET is a group selected from among formulas (IIa) (IIb) (IIc) (IId) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD and pain diseases.
• US8877745B2
  申请人：——

  公开号：US8877745B2

  公开（公告）日：2014-11-04