6-methoxy-2-methylpiperidine-1-carbaldehyde | 344746-97-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 6-methoxy-2-methylpiperidine-1-carbaldehyde
• 英文别名: 1-Piperidinecarboxaldehyde, 2-methoxy-6-methyl-；2-methoxy-6-methylpiperidine-1-carbaldehyde
• CAS: 344746-97-0
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: WWAZUFSAFGOEJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-methoxy-2-methylpiperidine-1-carbaldehyde 生成 5,6-didehydro-2-methylpiridine-1-carbaldehyde
  参考文献：
  名称：

  Palasz, Peter D.; Utley, James H. P.; Hardstone, J. David, Journal of the Chemical Society. Perkin transactions II, 1984, # 4, p. 807 - 814

  摘要：

  DOI：
• 作为产物：
  描述：

  甲醇 、 2-methylpiperidine-1-carbaldehyde 在 N,N,N,N-tetraethylammonium tetrafluoroborate 作用下， 以98%的产率得到6-methoxy-2-methylpiperidine-1-carbaldehyde
  参考文献：
  名称：

  High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

  摘要：

  N-Protecting groups of alpha-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into alpha'-methoxylated compounds, while N-cyano derivatives changed into alpha-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the alpha-methoxylated compounds protected with cyano group afforded alpha,alpha-disubstituted cyclic amines. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.060

文献信息

• PALASZ, P. D.;UTLEY, J. H. P.;HARDSTONE, J. D., J. CHEM. SOC. PERKIN TRANS., 1984, N 4, 807-813
  作者：PALASZ, P. D.、UTLEY, J. H. P.、HARDSTONE, J. D.

  DOI：——

  日期：——
• Palasz, Peter D.; Utley, James H. P.; Hardstone, J. David, Journal of the Chemical Society. Perkin transactions II, 1984, # 4, p. 807 - 814
  作者：Palasz, Peter D.、Utley, James H. P.、Hardstone, J. David

  DOI：——

  日期：——
• High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines
  作者：Samuel S. Libendi、Yosuke Demizu、Yoshihiro Matsumura、Osamu Onomura

  DOI：10.1016/j.tet.2008.02.060

  日期：2008.4

  N-Protecting groups of alpha-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into alpha'-methoxylated compounds, while N-cyano derivatives changed into alpha-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the alpha-methoxylated compounds protected with cyano group afforded alpha,alpha-disubstituted cyclic amines. (c) 2008 Elsevier Ltd. All rights reserved.